Article · Volume 5, Issue 19S · pp. 28–31

Studies on diuretic and laxative activity of bark extracts of Spondias pinnata (Linn. f) Kurz

S. Mondal¹, GK. Dash¹, S. Acharyya¹, DK. Brahma¹, S. Bal²

¹Matushree V. B. Manvar College of Pharmacy, Dumiyani, Rajkot district, Gujarat -360 440, India.
²Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, Orissa-751 015, India.

Abstract

The diuretic and laxative activity of different extracts of the barks of Spondias pinnata (Linn. f) Kurz (Family: Rubiaceae) were studied in Wistar albino rats. Furosemide (10 mg/kg, p.o.) and agar-agar (300 mg/kg, p.o.) were used as reference standards respectively for activity comparison. The chloroform and methanol extracts produced significant diuretic and laxative activity. On the other hand, the petroleum ether extract did not reveal significant activity. Urinary levels of sodium, potassium (by flame photometry) and chloride (by titrimetry) were estimated.

Keywords: acute toxicity study; agar-agar; diuretic activity; furosemide; laxative activity; Spondias pinnata

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