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PM · Lens · The impact of the Uighur medicine abnormal savda munziq on antitumor and antioxidant activity in a S180 and Ehrlich ascites carcinoma mouse tumor model

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Article · Volume 8, Issue 30 · pp. 141–148

The impact of the Uighur medicine abnormal savda munziq on antitumor and antioxidant activity in a S180 and Ehrlich ascites carcinoma mouse tumor model

Ainiwaer Aikemu2,3, Abdiryim Yusup3, Anwar Umar4,5, Bénédicte Berké4,5, Nicholas Moore4,5, Halmurat Upur3,4

  1. 1Departments of, University, 830011 Urumqi, Xinjiang People’s Republic of China.
  2. 2Drug Analysis.
  3. 3Traditional Uighur Medicine and.
  4. 4Pharmacology, Xinjiang Medical University, 830011 Urumqi, Xinjiang People’s Republic of China.
  5. 5Department of Pharmacology, University Victor Segalen Bordeaux 2, 33076 Bordeaux, France.

Abstract

Aim: This study was designed to study the antitumor and antioxidant activity of Uighur medicine abnormal savda munziq (ASMq) in the S180 and Ehrlich ascites carcinoma mice tumor model.Materials and Methods: The serum levels of superoxide dismutase (SOD), malonaldehyde (MDA), and glutathione-catalase (GSH-PX) were analyzed, and the mice were also subjected to a hypoxia tolerance test. Their climbing ability was also analyzed.Results: The findings of the study revealed that ASMq-treatment leads to an increase in blood serum SOD and GSH-PX levels but a decrease in blood serum MDA levels. Moreover, ASMq-treatment enhanced the survival time of mice maintained under hypoxic conditions and improved their mice climbing ability.Conclusions: The results of this study indicate that ASMq has obvious antitumor and antioxidative effects.

Keywords: Abnormal savda munziq; antioxidant; antitumor

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