Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract
1,2★, 1,2, 2★ Corresponding author
- 1Faculty of Pharmacy, Rajasthan University of Health Sciences, Jaipur.
- 2Department of Pharmacognosy, Alwar College of Pharmacy, Alwar, Rajasthan, India.
CORRESPONDENCE
Mahesh Kumar
Faculty of Pharmacy, Rajasthan University of Health Sciences, Jaipur.
Volume 9, Issue 5S · pp. s23–s26 · 2017 · DOI: 10.4103/pr.pr_18_17
ABSTRACT
Background: Indian traditional system of medicine uses Pithecellobium dulce for the treatment of diabetes mellitus.Objectives: This study aims to develop an extract rich in saponins derived from seeds of the plant and to evaluate its antihyperglycemic potential in vitro and in vivo.Materials and Methods: Defatted seeds were extracted with methanol and processed to afford saponin-enriched fraction (PDSEF). The fraction was evaluated for α-glucosidase and α-amylase inhibition.Results: PDSEF showed superior enzyme inhibition compared to acarbose and was safe up to 2000 mg/kg.Conclusion: PDSEF displayed excellent antihyperglycemic activity in vitro and in vivo.
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Kumar, M., Govindrajan, J., & Nyola, N. K. (2017). Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract. Pharmacognosy Research, 9(5S), s23–s26. https://doi.org/10.4103/pr.pr_18_17