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PR · Lens · Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract

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Article · Volume 9, Issue 5S · pp. s23–s26

Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract

Mahesh Kumar1,2, Jeyabalan Govindrajan1,2, Narendra Kumar Nyola2

  1. 1Faculty of Pharmacy, Rajasthan University of Health Sciences, Jaipur.
  2. 2Department of Pharmacognosy, Alwar College of Pharmacy, Alwar, Rajasthan, India.

Abstract

Background: Indian traditional system of medicine uses Pithecellobium dulce for the treatment of diabetes mellitus.Objectives: This study aims to develop an extract rich in saponins derived from seeds of the plant and to evaluate its antihyperglycemic potential in vitro and in vivo.Materials and Methods: Defatted seeds were extracted with methanol and processed to afford saponin-enriched fraction (PDSEF). The fraction was evaluated for α-glucosidase and α-amylase inhibition.Results: PDSEF showed superior enzyme inhibition compared to acarbose and was safe up to 2000 mg/kg.Conclusion: PDSEF displayed excellent antihyperglycemic activity in vitro and in vivo.

Keywords: Antihyperglycemic; Pithecellobium dulce; Saponins; α-amylase; α-glucosidase

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