Evaluation of Therapeutic Effect of Mg doped ZnS Nano Particle and Bougainvillea glabra Flower Fraction on HepG2 Cell Lines

ABSTRACT

Diabetes mellitus is chronic disease which causes ill effects on human health. Over many years, a number of research works undergone to control diabetes mellitus among humans. Most of the researchers contributed various drugs for controlling diabetes mellitus. It is observed that drugs either causing side effects or efficiency is very less. Hence, the present study is formulated to find out efficient drug to control diabetes mellitus, which is free from side effects. Zinc has potential antioxidant activity. Hence it is selected as drug delivery agent as in the form of Mg doped ZnS nanoparticle. Herbal formulations always showed potential biological activities. and herbal delivery with nanoparticle showed enhanced antidiabetic activity. The Mg doped ZnS nanoparticle and Bougainvillea glabra flower fraction were evaluated for their cytotoxic nature against HepG2 cell lines. Glucose uptake activity and α-Glucosidase activity were also estimated. The results showed potential antidiabetic activity and antioxidant activity with negligible cytotoxicity, signifying that Mg doped ZnS nano particle and Bougainvillea glabra flower fraction as potential candidate for the treatment of diabetes.

KEYWORDS

• Antioxidant activity
• Bougainvillea glabra
• cytotoxicity
• HepG2 cell lines
• Mg doped nanoparticle

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• DOI10.5530/ajbls.2021.10.27Copy

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