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Asian Journal of Biological and Life sciencesNOW IN
Article

Evaluation of Cytotoxic Potential of Ethanolic and Acetone Extract of Abelmoschus moschatus on Hep G2 Cell Lines

Rani Sebastian1★, Gomathi Venkatachalam2, Umamaheswari D3, Sakthi Abirami M4, Venkateswarlu BS1★ Corresponding author

  1. 1Vinayaka Mission’s College of Pharmacy, Yercad Main Road, Salem, Vinayaka Mission’s Research Foundation (Deemed to be University), Ariyanur, Salem, Tamil Nadu, INDIA.
  2. 2Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Ariyanur, Salem, Tamil Nadu, INDIA.
  3. 3Department of Pharmaceutical Analysis, Vinayaka Mission’s College of Pharmacy, Salem, Vinayaka Mission’s Research Foundation (Deemed to be University), Ariyanur, Salem, Tamil Nadu, INDIA.
  4. 4Department of Pharmacology, Madras Medical College, Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

Rani Sebastian

Vinayaka Mission’s College of Pharmacy, Yercad Main Road, Salem, Vinayaka Mission’s Research Foundation (Deemed to be University), Ariyanur, Salem, Tamil Nadu, INDIA.

ranisalapatt@yahoo.com

Received: 13-01-2022; Revised: 12-02-2022; Accepted: 27-02-2022.

Volume 11, Issue 1 · pp. 70–76 · PUBLISHED · DOI: 10.5530/ajbls.2022.11.10

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ABSTRACT

This study aims to highlight the cytotoxic effects of Abelmoschus moschatus on Hep G2 cell lines by methylthiazoltetrazolium (MTT)-cleavage assay. The yellow tetrazolium salt MTT is converted by mitochondrial dehydrogenases of metabolically active cells to an insoluble purple formazan product, which was then solubilized with dimethylsulfoxide. The optical density of this homogeneous solution was suitable for a precise spectrophotometric measurement by a plate reader at a wavelength of 570 nm. The cytotoxic effect of acetone extract was shown at 92.01 μg/ml and ethanol extract was shown at 72.16 μg/ml respectively when compared with the standard Doxorubicin. The results showed that both the extracts posess significant cytotoxic activity. The studies reveal that natural plant extract has the ability to work as a defense by enhancing the immune system against cancer.

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    Sebastian, R., Venkatachalam, G., D, U., M, S. A., & BS, V. (). Evaluation of Cytotoxic Potential of Ethanolic and Acetone Extract of Abelmoschus moschatus on Hep G2 Cell Lines. Asian Journal of Biological and Life sciences, 11(1), 70–76. https://doi.org/10.5530/ajbls.2022.11.10