Volume 7, Issue 2

25-10-2021 · pp. 13–28 · 4 articles

In this issue

Article
Rapid Transformational Therapy (RTT): An Emerging Non-invasive Therapeutic Modality
Savitha Raveendran, Chandrasekaran Kaliaperumal
pp. 13–14 · DOI: 10.5530/bems.7.2.6 · Published
We write to highlight an emerging non-invasive therapeutic option that can be potentially used for various medical ailments. RTT is Rapid Transformational Therapy, a hybrid therapy developed by Marisa Peer in England, UK…

Article
Molecular Profiling of Neprilysin Expression and its Interactions with SARS-CoV-2 Spike Proteins to Develop Evidence Base Pharmacological Approaches for Therapeutic Intervention
Arun HS Kumar
pp. 15–20 · DOI: 10.5530/bems.7.2.7 · Published
Introduction:Neprilysin due to its peptidase activity is involved in several physiological and pathological processes. Recently our group has reported the association of neprilysin with angiotensin-converting enzyme 2 (A…
Article
Network Pharmacology Analysis of Orally Bioavailable SARS-CoV-2 Protease Inhibitor Shows Synergistic Targets to Improve Clinical Efficacy
Arun HS Kumar
pp. 21–24 · DOI: 10.5530/bems.7.2.8 · Published
Introduction: Orally bioavailable SARS-CoV-2 antiviral drugs will significantly improve the clinical management of the disease. PF07321332 (PF32) one such orally bioavailable SARS- CoV-2 protease inhibitor which can be h…
Article
Modelling the Efficacy of Neprilysin from Various Species in Degrading Different Amyloid-β peptides: Potential Application in Development of Therapeutics for Alzheimer’s Disease
Arun HS Kumar
pp. 25–28 · DOI: 10.5530/bems.7.2.9 · Published
Recombinant neprilysin due to its degradation potential against Amyloid-β (Aβ) peptides has been looked at as a potential therapeutic candidate for treating Alzheimer’s disease (AD). However the enzymatic activity of nep…