Volume 1, Issue 3

Subhankar Chakraborty

pp. 1–2 · DOI: 10.5530/ax.2011.3.1 · 2011

Diabetes mellitus is a global epidemic. In the United States alone, the National Diabetes Information Clearinghouse (NDCI), a joint service of the National Institute of Diabetes and Digestive and Kidney Diseases and the …

Alba Naudí, Mariona Jové, Victòria Ayala, Manuel Portero-Otín, Gustavo Barja, Reinald Pamplona

pp. 3–12 · DOI: 10.5530/ax.2011.3.2 · 2011

Oxidative stress resulting from biomolecular oxidative damage due to the imbalance between reactive species production and antioxidant response has become an universal constraint of life-history evolution in animals and …

Jad El-Hoss, Aaron S. Micallef, Kathryn E. Fairfull-Smith, Steven E. Bottle, David G. Little, Aaron Schindeler

pp. 13–18 · DOI: 10.5530/ax.2011.3.3 · 2011

Background:Type 1 Neurofibromatosis (NF1) is a genetic disorder linked to mutations of the NF1 gene. Clinical symptoms are varied, but hallmark features of the disease include skin pigmentation anomalies (café au lait ma…

Henrique Fillmann, Juliana Tieppo, Nélson Alexandre Kretzmann Filho, Graziella Rodrigues, Jaqueline Nascimento Picada, Julian Panés, Norma Possa Marroni

pp. 19–26 · DOI: 10.5530/ax.2011.3.4 · 2011

Introduction:The gastrointestinal system is frequently affected in patients with diabetes mellitus (DM). Some of these alterations are due to oxidative stress and the production of free radicals. The present study was de…

Ana Luisa Miranda-Vilela, Penha Cristina Zaidan Alves, Arthur Kenji Akimoto, Graciana Souza Lordelo, Maria de Nazaré Klautau-Guimarães, Cesar Koppe Grisolia

pp. 27–39 · DOI: 10.5530/ax.2011.3.5 · 2011

Context:Exhausting exercise, increasing reactive oxygen species, can overwhelm the endogenous antioxidant system’s capacity, resulting in oxidative damage to DNA. Deficient antioxidant defenses, influenced by certain gen…

Taofeek Olakunle Ajiboye, Musa Toyin Yakubu, Adenike Temidayo Oladiji

pp. 40–47 · DOI: 10.5530/ax.2011.3.6

The electrophilic, free radical and reactive oxygen species scavenging and detoxification potentials of Lophiraalata stem bark was evaluated. L. alata stem bark effectively scavenged DPPH radical, superoxideion and hydro…

Varunraj Sendamangalam, One Kyun Choi, Youngwoo Seo, Don-Shik Kim

pp. 48–55 · DOI: 10.5530/ax.2011.3.7 · 2011

Natural polyphenols, gallic acid, tannic acid, quercetin and salicylic acid, were investigated for their antimicrobial and antioxidant activities against Streptococcus mutans. Ascorbic acid, well known for its antimicrob…

Smitha Jayaram, Shylaja M. Dharmesh

pp. 56–65 · DOI: 10.5530/ax.2011.3.8 · 2011

Background:Andrographis serpyllifolia, used as a medicinal plant in traditional practices in India, where in cancer patients are treated using the leaves of A. serpyllifolia. The crude extracts of A. serpyllifolia not on…

Mani RP, Pandey Awanish, Goswami Shambaditya, Tripathi Poonam, Kumudhavalli V, Singh Ajay Pratap

pp. 66–69 · DOI: 10.5530/ax.2011.3.9 · 2011

Introduction:Antioxidants are micronutrients that have gained importance in recent years due to their ability to neutralize free radicals or their actions. Sesbania sesban (L) Merr is an ancient plant which is traditiona…

Patrick Amoateng, George Assumeng Koffuor, Kwame Sarpong, Kwabena Oteng Agyapong

pp. 70–78 · DOI: 10.5530/ax.2011.3.10 · 2011

Background:Synedrella nodiflora (L.) Gaertn. (Asteraceae), a native Ghanaian shrub, has been used for the treatment of epilepsy, hiccup and threatened abortion. The present study aimed at investigating the possible mecha…

Govindappa M, Bharath N, Shruthi HB, Gustavo Santoyo

pp. 79–85 · DOI: 10.5530/ax.2011.3.11 · 2011

Introduction: The species Crotalaria pallida, which belongs to the Fabaceae family (Sub-family Faboideae), the members of which are herbs, shrubs and trees found in both temperate and tropical areas. All parts of the pla…

Rajesh Mandade, S.A. Sreenivas, Avijit Choudhury

pp. 87–93 · DOI: 10.5530/ax.2011.3.12 · 2011

Free radicals induce numerous diseases by lipid peroxidation, protein peroxidation, and DNA damage. It has been reported that numerous plant extracts have antioxidant activities to scavenge free radicals. In the present …

Owolabi, MA, Jaja, SI, Olatunji, OJ, Oyekanmi, OO, Adepoju, S

pp. 94–101 · DOI: 10.5530/ax.2011.3.13 · 2011

Introduction: Diabetes is a disease that constitutes multiple sources of free radicals, thus oxidative stress is expected to have a double impact. Since oxidative stress is mediated by hyperglycemia-induced generation of…