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Free Radicals and AntioxidantsNOW IN
Review

Anticancer Properties and Clinical Trials of Coumarins: A Review

Hazem M Shaheen1, Jean Noël Nyemb2★, Narimane Segueni3, Jennifer George4, Vishwanath R Patil4, Gaber El-Saber Batiha1★ Corresponding author

  1. 1Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, EGYPT.
  2. 2Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Kaele, CAMEROON.
  3. 3Faculty of Medicine, University Salah Boubnider Constantine 3, Constantine, ALGERIA.
  4. 4Department of Chemistry, University of Mumbai, Mumbai, Maharashtra, INDIA.

CORRESPONDENCE

Jean Noël Nyemb

Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Kaele, CAMEROON.

nyembjeannoel@gmail.com

Received: 09-08-2022; Revised: 27-08-2022; Accepted: 18-09-2022.

Volume 12, Issue 2 · pp. 41–48 · PUBLISHED · DOI: 10.5530/fra.2022.2.8

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ABSTRACT

Cancer has evolved as one of the most common causes of mortality, worldwide. Though numerous chemotherapeutic treatments are available, their side effects such as cytotoxicity and drug resistance form a big problem during the cancer treatment. Recent studies of anticancer activities conducted on natural products isolated from plants, namely coumarin and related compounds, prove them to be a promising drug candidate in cancer treatments. Efforts made by the scientists to design and develop novel anti-cancer agents using coumarins as lead compounds and study their effectiveness using Structural Activity Relationship is worth appreciating. This review, therefore, focuses on the recent progress in the discovery of coumarin derivatives with potential antitumor activity. It also summarizes their structure- activity relationship, and mechanism of action studies.

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    Shaheen, H. M., Nyemb, J. N., Segueni, N., George, J., Patil, V. R., & Batiha, G. E. (). Anticancer Properties and Clinical Trials of Coumarins: A Review. Free Radicals and Antioxidants, 12(2), 41–48. https://doi.org/10.5530/fra.2022.2.8