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Free Radicals and AntioxidantsNOW IN
Review

Are we over estimating serum oxidative stress/lipid peroxidation in alcoholic liver diseases? A review

Sangappa Virupaxappa Kashinakunti1★, Gurupadappa Shantappa Kallaganada2, Manjula Rangappa3, Kavitha Hiremath4, Sheshidhar Bannale5★ Corresponding author

  1. 1Associate Professor, Department of Biochemistry, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India.
  2. 2Professor and HOD Department of Biochemistry, Shimoga Institute of Medical Sciences, Shimoga-577201, Karnataka, India.
  3. 3Assistant Professor Department of Community Medicine, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India.
  4. 4Assistant Professor Department of Biochemistry, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India.
  5. 5Assistant Professor Department of Pharmacology, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India.

CORRESPONDENCE

Sangappa Virupaxappa Kashinakunti

Associate Professor, Department of Biochemistry, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India.

drsvkashinakunti@yahoo.co.in

Received: 30-05-2012; Revised: 20-07-2012; Accepted: 06-08-2012.

Volume 2, Issue 3 · pp. 1–9 · PUBLISHED · DOI: 10.5530/ax.2012.3.1

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ABSTRACT

Almost 95% of alcohol is metabolized by the liver but a small fraction is also metabolized in other organs like brain, heart, kidney, pancreas, skeletal muscle etc. Alcohol is metabolized by oxidative and non-oxidative pathways. Alcohol metabolism results in the generation of reactive molecule acetaldehyde and reactive oxygen species (ROS), which in turn leads to oxidative stress. The reactive metabolic products of alcohol and ROS cause lipid peroxidation, the lipid peroxidation products (LPP) like malondialdehyde (MDA) enter the circulation. In most of the studies on alcoholic liver disease the serum levels of ROS/LPP were estimated, but these products are also contributed by other tissues. Even though the maximum amount of ROS/LPP is produced by the liver, after reaching other organs through circulation, ROS/LPP further multiply and again reach the circulation. At this point by measuring the ROS/LPP in blood and claiming it’s of liver, are we estimating it correctly?

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    Kashinakunti, S. V., Kallaganada, G. S., Rangappa, M., Hiremath, K., & Bannale, S. (). Are we over estimating serum oxidative stress/lipid peroxidation in alcoholic liver diseases? A review. Free Radicals and Antioxidants, 2(3), 1–9. https://doi.org/10.5530/ax.2012.3.1