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Indian Journal of Natural ProductsNOW IN
Article

Antibacterial Potential of Quercetin against IBD Bacterial Isolates and Cytotoxicity against Colorectal Cancer

Sanjay Mishra1,2★, Damita Cota1, Sunil Satyappa Jalalpure1,2★ Corresponding author

  1. 1Department of Natural Product Research, KAHER’s Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA.
  2. 2Department of Pharmaceutics, KAHER’s College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA.

CORRESPONDENCE

Sanjay Mishra

Department of Natural Product Research, KAHER’s Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi, Karnataka, INDIA.

sanjaymishra@klepharm.edu

Volume 35, Issue 1 · pp. 16–18 · PUBLISHED 2021 · DOI: 10.5530/ijnp.2021.1.4

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ABSTRACT

Background: Quercetin is known for its vast pharmacological activities in recent years. It has shown beneficial effects in animal models of colitis. Purpose: The effectiveness of quercetin in human IBD is limited. Results from these pre-clinical studies indicate an opportunity for developing anti-colitic polyphenol treatments.Methods: In the present study. Quercetin was evaluated for its antimicrobial potential against clinical isolates of IBD patients (HM95, HM233, HM251, HM615). Cytotoxicity was determined against human colorectal adenocarcinoma cells (Caco2, COLO.205, HT.29), whereas, cytocompatibility against normal rat intestinal epithelial (IEC-6).Results: It showed an MIC value of 5 mg/mL and MBC value of 10 mg/Ml against all the four bacterial isolates. A dose dependent response was observed against the cell lines.Conclusion: Antibacterial activity of Quercetin was found against the bacterial isolates from CD and UC patients used in the study. Cytotoxity was observed against colorectal cancer cells with minimal effect on normal cells. However, further investigations are required to understand its precise mechanism.

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    Mishra, S., Cota, D., & Jalalpure, S. S. (2021). Antibacterial Potential of Quercetin against IBD Bacterial Isolates and Cytotoxicity against Colorectal Cancer. Indian Journal of Natural Products, 35(1), 16–18. https://doi.org/10.5530/ijnp.2021.1.4