Comparison of Safety and Efficacy of Different Class of Anti-hypertensive Drugs Prescribed in Patients with Hypertension

ABSTRACT

Background:Hypertension is considered as key indicator for various cardiovascular diseases. Blood pressure is the pressure of blood on arterial walls. The use of antihypertensive drugs is increased worldwide. Hypertension treatment strategy varies widely in terms of initial drug of choice from diuretic to ACEIs/ ARBs/ CCBs and from monotherapy to combination therapy. Objectives: To compare the safety and efficacy of different class of Antihypertensive drugs prescribed in patients with hypertension. Methods: A Prospective observational and longitudinal study which included 150 newly diagnosed hypertensive patients attending medical outpatient department of Sheth HJ Mahagujarat Hospital, Nadiad. Demographic details and baseline blood pressure of the patients were recorded. Patients were followed up after 15 days and one-month period of treatment. Adverse effects were noted at the time of treatment. Results: The mean age of patients 55 years in which both genders were equally exposed. Diabetes Mellitus was major associated condition and patients above 50 years were at high risk for hypertension. Patients receiving ARBs showed significant control in blood pressure (p=0.03) as monotherapy when compared with other Anti-hypertensive drugs. In FDCs, Losartan + Hydrochlorothiazide (p=0.03, 0.005), Telmisartan + Metoprolol Succinate (p=0.00002, 0.005) and Losartan + Amlodipine (p=0.03, 0.0003) proved significance. Reported adverse effects were recorded at the time of treatment as safety parameter. Conclusion: Hypertension was most common in patients above 50 years. ARBs were most prescribed as monotherapy. In FDCs most suitable combinations were with ARBs with few adverse effects.

KEYWORDS

• Hypertension
• Safety
• Efficacy
• ARBs
• FDCs

Showing references and in-text citations exactly as published.

• DOI10.5530/ijopp.12.4.54Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPP.

• Article · VOLUME 12, ISSUE 4Assessment of Inhalation Techniques in COPD and Asthma Patients using Metered Dose Inhaler and Rota-halerJalpa Suthar, Zalak A Patel, Bhavik Shelat · pp. 217–224Research ArticleSame type: Article
• Article · VOLUME 12, ISSUE 4Development of Point-of-care Paper Based Strip for the Detection of Simple Antipyretic-analgesic DrugsGVSR Pavan Kumar, K Srinivasa Rao · pp. 225–228Research ArticleSame type: Article
• Article · VOLUME 12, ISSUE 4Interventional Study Based on Prescription Errors in the Inpatient Units of a Tertiary Care Hospital in CalicutSuresh Arumugam, Sneha Prakash, Sreerag Azhakath, Lydia Abraham, Lakshmi Prakashan, Anusree Anaparakkal · pp. 229–233Research ArticleSame type: Article
• Article · VOLUME 12, ISSUE 4Venous Thromboembolism Prophylaxis: A Survey among the Medical Staff of Intensive Care Unit and Surgery Ward in Tertiary Care Teaching HospitalVinod Kumar, Shraddha P Devarshi · pp. 234–238Research ArticleSame type: Article