Anaphylatic Shock with Off-Label use of Oxaliplatin in Ovarian Cancer: A Rare Case Report

ABSTRACT

Oxaliplatin is a third-generation platinum compound that acts on DNA (Deoxyribonucleic acid) to form inta/inter stand cross-linking and thereby affecting DNA base pairing, replication, gene transcription, and leading to cell death. Anaphylactic reactions associated with platinum compounds are potentially life threatening. A 67-year-old female patient, a known case of carcinoma ovary, previously underwent surgery and multiple lines of chemotherapy now presented with progressive disease. She got admitted for evaluation and management. She recently presented with complaints of fever and fatigue. The patient had a history of allergy to carboplatin. After pre-chemo evaluation, the first cycle of chemotherapy was started with the combination of Cyclophosphamide, Oxaliplatin, and Bevacizumab. Sudden after the administration of Oxaliplatin patient had developed fatigue, weakness along breathing difficulty, change of sound, and cyanosis. The patient was shifted to MICU (Medical Intensive Care Unit) and managed. After that remaining chemotherapy was administered successfully and the patient got discharged. This case highlights the consequence of Oxaliplatin induced anaphylactic shock which is rare but potentially fatal and so oncologists should be vigilant when patients have signs or symptoms similar to anaphylactic reactions.

KEYWORDS

• Oxaliplatin
• Ovarian cancer
• Chemotherapy
• Platinum compounds
• Anaphylactic reactions

Showing references and in-text citations exactly as published.

• DOI10.5530/ijopp.14.4.66Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPP.

• Article · VOLUME 14, ISSUE 4AKT 3 Induced Hepatitis: Case ReportCyril Sajan, Priyanshi Rakesh Shah, Mahek Mistry · pp. 287–290Case ReportSame type: Article
• Article · VOLUME 14, ISSUE 4Case Report on Anti-Tubercular Drug Induced Hepatoxicity / Modified ATTM Saru Khan, Basil Sunny, Rithuvaren M Krishnan · pp. 294–297Case ReportSame type: Article
• Article · VOLUME 14, ISSUE 4Case Report on Patent Ductus Arteriosus with Eisenmenger SyndromeDoody Thomas, Neha Maria Augustine, Abhirami Azad, Femy Thomas, Midhuna Saju · pp. 298–300Case ReportSame type: Article
• Article · VOLUME 14, ISSUE 4First Dose Phenomenon in a Scorpion Sting Patient Being Treated with Prazosin: A Case ReportReshma Manik, Jagruti Arun Pashte, Varsha Iranna Dalal, Prasad Bali · pp. 301–303Case ReportSame type: Article