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Neurodegenerative Diseases: The Effect of Omega-3 Fatty Acids on Neuroinflammation

Priyadharshini R1, Sreelakshmi S1, Tanuvarthini S.B1, Aishwarya S1, Hema V1, Milagrin Xavier1★★ Corresponding author

  1. 1Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy (Affiliated to the Tamil Nadu Dr. M.G.R. Medical University), Elayampalayam, Namakkal, Chennai, Tamil Nadu, INDIA..

CORRESPONDENCE

Milagrin Xavier

Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy (Affiliated to the Tamil Nadu Dr. M.G.R. Medical University), Elayampalayam, Namakkal, Chennai, Tamil Nadu, INDIA..

milagrinxavier98@gmail.com

Received: 01-12-2024; Revised: 14-02-2025; Accepted: 29-04-2025.

Volume 18, Issue 4 · pp. 362–366 · PUBLISHED · DOI: 10.5530/ijopp.20250251

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ABSTRACT

Omega-3 fatty acids’ anti-inflammatory qualities and impact on the integrity of neuronal membranes make them promising for the treatment of neurodegenerative diseases including Parkinson’s and Alzheimer’s. Omega-3 and omega-6 Polyunsaturated Fatty Acids (PUFAs) influence neuroinflammation and cognitive function, making them essential for brain health. Neurodegeneration and mental disorders are associated with deficiency in omega-3 polyunsaturated fats. According to clinical research, taking omega-3 supplements-especially those containing DHA and EPA-may help with cognitive performance and lower neuroinflammation in people with Parkinson’s and Alzheimer’s illnesses. Mechanistically, omega-3 PUFAs control inflammatory pathways and synaptic function, while DHA suppresses tau protein phosphorylation and Aβ buildup. Omega-3 PUFAs can be obtained through diet, such as fatty fish, although supplementation may be required, particularly in populations with limited consumption or conversion capacity. One useful application of omega-3 fatty acid fortification is providing easy methods to integrate it in everyday diets. Overall, study is needed to determine whether omega-3 fatty acids can prevent or treat neurodegenerative diseases.

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    R, P., S, S., S.B, T., S, A., V, H., & Xavier, M. (). Neurodegenerative Diseases: The Effect of Omega-3 Fatty Acids on Neuroinflammation. Indian Journal of Pharmacy Practice, 18(4), 362–366. https://doi.org/10.5530/ijopp.20250251