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Indian Journal of Pharmacy PracticeNOW IN
Review

Gastroprotective agents use with Nonsteroidal Antiinflammatory Drugs: an Overview

Mahendra Kumar BJ1★, Naveen KHD1, Chakrapani K1, Sowmya M1★ Corresponding author

  1. 1Department of Pharmacy Practice, SAC College, BG Nagara - 571448, Karnataka, India.

CORRESPONDENCE

Mahendra Kumar BJ

Department of Pharmacy Practice, SAC College, BG Nagara - 571448, Karnataka, India.

bjmahendra2003@yahoo.co.in

Received: 08-01-2012; Accepted: 17-02-2012.

Volume 5, Issue 1 · pp. 16–20 · PUBLISHED · DOI:

View on IJPP original site ↗

ABSTRACT

Non-steroidal Anti-inflammatory Drugs (NSAIDs) are widely used in clinical set up for patient care because of their analgesic, anti-inflammatory and antipyretic properties. Most of the NSAIDs can cause gastrointestinal damage by inhibiting cyclooxygenase-1 (COX-1) enzyme. Strategies are recommended to reduce the risk of NSAIDs associated gastrointestinal (GI) adverse events. Prevention of GI morbidity induced by NSAIDs with co-prescription of Gastro protective agents (GPA) has been clinically approved. Administration of GPA in all NSAIDs users is unnecessary. Selection of GPA mainly depends upon the NSAID related GI risk and also the patient risk factor for GI complication as well as efficacy and tolerability of both NSAID and GPA.

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    BJ, M. K., KHD, N., K, C., & M, S. (). Gastroprotective agents use with Nonsteroidal Antiinflammatory Drugs: an Overview. Indian Journal of Pharmacy Practice, 5(1), 16–20.