Study of FE (III) Hydroxide Polymaltose Complex to Correct Anemia in Cancer Patients
Pallavi H.S1★, Nirzarini N.S1★ Corresponding author
- 1A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Mota Bazar, Vallabh Vidyanagar- 388120, Anand, Gujarat, INDIA.
CORRESPONDENCE
Pallavi H.S
A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Mota Bazar, Vallabh Vidyanagar- 388120, Anand, Gujarat, INDIA.
Received: 19-09-2012; Revised: 10-10-2012; Accepted: 25-11-2012.
Volume 5, Issue 4 · pp. 56–60 · PUBLISHED · DOI:
ABSTRACT
Introduction:Anemia of cancer is characterized by ineffective erythropoiesis, which is due to a number of factors. One of the most important among these is abnormal iron metabolism. There is also 'functional failure' due to retention of iron in macrophages. Hence iron supplementation 2+ forms an important part for the treatment of anemia in cancer patients. Oral iron supplements, usually in the form of ferrous (Fe ) salts, are toxic to the gastrointestinal mucosa, leading to intolerance, resulting in poor compliance and failure of treatment. The sugar derivative maltose strongly 3+ chelates iron, and stabilizes in the less toxic ferric (Fe ) form. This chelated form of iron shows high bioavailability which eliminates the need for frequent dosing and therefore improves compliance. Materials and Method:This was a prospective, single centred, open label, nonrandomised study involving 20 patients of whom 17 completed the study. The patients were treated with ferric hydroxide polymaltose complex syrup (50mg/5ml) for 8 weeks. Results:At the end of 8 weeks, there was a significant increase in haemoglobin of the patients (from 9.41±1.24 to 10.92±0.91 g/dL, mean±s.d. P< 0.0001, paired t-test, t = 7.065, df = 16, confidence interval - 0.05.). Out of 17, 7 patients i.e. 41.18% showed a ≥ 2 g/dl rise in hemoglobin during or at the end of the treatment. Mean time required to achieve this rise in hemoglobin is found to be 7 weeks. Conclusion:The results demonstrate that Fe (III) hydroxide polymaltose complex is effective in improving hemoglobin levels in anemic cancer patients.
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H.S, P., & N.S, N. (). Study of FE (III) Hydroxide Polymaltose Complex to Correct Anemia in Cancer Patients. Indian Journal of Pharmacy Practice, 5(4), 56–60.