Oral Drotaverine and Aceclofenac Combination versus Aceclofenac alone for Postoperative Pain Relief: A Prospective Randomized Clinical Trial
Vinod KM1, Ashish D1★★ Corresponding author
- 1Department of General Surgery, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi – 110060, INDIA.
CORRESPONDENCE
Ashish D
Department of General Surgery, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi – 110060, INDIA.
Received: 21-11-2013; Accepted: 14-12-2013.
Volume 6, Issue 4 · pp. 18–21 · PUBLISHED · DOI:
ABSTRACT
Objective:To compare the efficacy of Drotaverine- Aceclofenac combination with Aceclofenac alone in treatment of postoperative spasm and pain. Methods: In a prospective Randomized Clinical Trial, patients undergoing laparoscopic surgeries not involving bowel resections were enrolled. Group 1 received 80 mg Drotaverine and 100 mg Aceclofenac combination while Group 2 received 100 mg Aceclofenac alone. Pain was assessed by a 10-point visual analog scale on day 1, 3 and 5 after surgery. Results: We recruited 70 cases in each group. Group 1 showed statistically significant reduction in pain scores at day 1, 3 and 5, postoperatively. The scores for Global assessment and general evaluation by doctor were statistically higher in group 1. Group 1 also experienced relatively less adverse events.Conclusion:Drotaverine with Aceclofenac combination is more effective than Aceclofenac alone in treatment of postoperative pain after laparoscopic procedures which do not involve bowel resections or extensive bowel handling.
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KM, V., & D, A. (). Oral Drotaverine and Aceclofenac Combination versus Aceclofenac alone for Postoperative Pain Relief: A Prospective Randomized Clinical Trial. Indian Journal of Pharmacy Practice, 6(4), 18–21.