Article · Volume 46, Issue 2 · pp. 185–191

Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues

N.K. Sathish¹, S Shahensha², M Irfan Ali¹, I.A. Chethan¹

¹Department of Pharmaceutical Chemistry, SAC College of Pharmacy, BG Nagara Mandya-571448, Karnataka, India.
²Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, KM Doddi, Mandya.

Abstract

Some new 2-[(E)-2-(substituted phenyl) ethenyl]-3-(2/4methyl phenyl) quinazolin-4(3H)-ones (Q1_a-f Q2_a-f have been synthesized from 3-(2- methyl phenyl) quinazolin-4(3H)-one (Q1) and 3-(4-methyl phenyl) quinazolin-4(3H)-one (Q2) by introducing different aromatic aldehydes. The synthesized compounds have been characterized by IR, ¹H NMR, ¹³C NMR and Mass spectral techniques and screened for anti-inflammatory activity by using carrageenan induced rat paw edema method. Compounds Q1a, Q1e, Q1f and Q2f showed potent activity when compared to diclofenac sodium as standard. Examination of the relationship between lipophilicity and anti-inflammatory activity of quinazolines showed poor correlation.

Keywords: Quinazoline; Anti-inflammatory activity; Lipophilicity; Diclofenac sodium

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