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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues

1★, 2, 1, 1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, SAC College of Pharmacy, BG Nagara Mandya-571448, Karnataka, India.
  2. 2Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, KM Doddi, Mandya.

CORRESPONDENCE

N.K. Sathish

*Address for Correspondence: Dr. NK Sathish, Professor, Dept.of Pharmaceutical Chemistry, SAC College of Pharmacy, BG Nagara - 571448, Mandya Dt. Karnataka

nksathish76@gmail.com

Received: 10-02-2011; Revised: 02-05-2011; Accepted: 24-11-2011.

Volume 46, Issue 2 · pp. 185–191 · 2012 · DOI:

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ABSTRACT

Some new 2-[(E)-2-(substituted phenyl) ethenyl]-3-(2/4methyl phenyl) quinazolin-4(3H)-ones (Q1a-f Q2a-f have been synthesized from 3-(2- methyl phenyl) quinazolin-4(3H)-one (Q1) and 3-(4-methyl phenyl) quinazolin-4(3H)-one (Q2) by introducing different aromatic aldehydes. The synthesized compounds have been characterized by IR, 1H NMR, 13C NMR and Mass spectral techniques and screened for anti-inflammatory activity by using carrageenan induced rat paw edema method. Compounds Q1a, Q1e, Q1f and Q2f showed potent activity when compared to diclofenac sodium as standard. Examination of the relationship between lipophilicity and anti-inflammatory activity of quinazolines showed poor correlation.

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    Sathish, N., Shahensha, S., Ali, M. I., & Chethan, I. (2012). Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues. Indian Journal of Pharmaceutical Education and Research, 46(2), 185–191.