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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones

1, 1★, 1, 1★ Corresponding author

  1. 1Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India.

CORRESPONDENCE

B. Jayalakshmi

*Address for Correspondence: B. Jayalakshmi, Asst. Prof., Department of Pharmaceutical Chemistry, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam - 638 183, Tamilnadu, India

bjayavasan@gmail.com

Received: 03-05-2011; Revised: 18-07-2011; Accepted: 17-12-2011.

Volume 46, Issue 3 · pp. 206–210 · 2012 · DOI:

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ABSTRACT

New 4-aryl substituted quinazolin-2-thiones were synthesized and confirmed by spectral studies like IR and NMR. Then screened for antimicrobial, analgesic, anti-inflammatory and CNS depressant activities. All the derivatives were showing the pharmacological activity mainly due to the presence of basic nucleus, quinazolin-2-thione and was modified with various substituents at 4th position with different aryl substituents. Among all the substituents, the halogen substituted compounds are comparatively more active.

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    Aslak, C., Jayalakshmi, B., Balasubramaniam, A., & Senthilkumar, N. (2012). Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones. Indian Journal of Pharmaceutical Education and Research, 46(3), 206–210.