Evaluation of Anti-ulcer Activity of Stem Bark Extract of Aphanmixis Polystachya in Experimental Rats

Aphanmixis polystachya (Amoora rohituka) is well known traditional plant in India. The plant is having laxative, anthelmintic, astringent, Immunosuppressive, potent antitumor activity and in-vitro antibacterial, antifungal activity. The aim was to search for anti-ulcer activity of aqueous and methanolic extract of Aphanmixis polystachya stem bark. Aqueous and methanolic extract of Aphanmixis polystachya stem bark was investigated for its potential to protect gastric mucosa against ulcers induced by Pylorus ligation method, indomethacin induced, Stress ulcer through cold water immersion. Ulcer index, free acidity, total acidity and Percentage protection were used for evaluation of anti ulcer activity. Pre-treatment with both Aphanmixis polystachya stem bark extracts in dose of 200 mg/kg significantly diminished the ulcer index and the % protection of ulcer compared with control group (p<0.05).Based on the studies we concluded that the methanolic and aqueous extracts of Aphanmixis polystachya stem bark might contain some active principles against ulcer healing.