Promoieties Used In Prodrug Design: A Review
Dhokchawle B. V1★, Gawad J. B.1, Kamble M. D.1, Tauro S. J.1, Bhandari A. B.2★ Corresponding author
- 1Department of Pharmaceutical Chemistry, St John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Thane-401404, Maharashtra.
- 2Dean, Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur-342001, Rajasthan.
CORRESPONDENCE
Dhokchawle B. V
Department of Pharmaceutical Chemistry, St John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Thane-401404, Maharashtra.
Received: 10-01-2014; Revised: 12-03-2014; Accepted: 04-04-2014.
Volume 48, Issue 2 · pp. 35–40 · PUBLISHED 2014 · DOI: 10.5530/ijper.48.2.5
ABSTRACT
Despite the success of various prodrugs, surprisingly no other reviews except a review on amino acids as promoieties, which elaborates about amino acids as prodrugs have been published to date. Therefore, we hope that this timely review using both marketed and investigational prodrugs as examples will be of interest for scientists working in the area of drug discovery and development as well as those working in the clinic. In the present commentary we have tried to summarize the different types of promoieties available for prodrug design. The examples of prodrugs using several promoeity are discussed with their advantages and future prospects. The properties and selection of promoieties for the prodrug design is a very crucial parameter in successful prodrug design.
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V, D. B., B., G. J., D., K. M., J., T. S., & B., B. A. (2014). Promoieties Used In Prodrug Design: A Review. Indian Journal of Pharmaceutical Education and Research, 48(2), 35–40. https://doi.org/10.5530/ijper.48.2.5