Spectrophotometric Method For Simultaneous Estimation of Montelukast Sodium and Ebastine in Bulk and Their Combined Tablet Dosage Form
Nikita N. Patel1★, Nikesh S. Rana1, Rajesh K. S1, Parag R.Patel1, Ujjaval Limbachiya1, T. Y. Pasha2★ Corresponding author
- 1Parul Institute of Pharmacy, Waghodia, Limda, Gujarat, India.
- 2Parul Institute of Pharmacy and Research, Waghodia, Limda, Gujarat, India.
CORRESPONDENCE
Nikita N. Patel
Parul Institute of Pharmacy, Waghodia, Limda, Gujarat, India.
Volume 48, Issue 2 · pp. 87–91 · PUBLISHED 2014 · DOI: 10.5530/ijper.48.2.12
ABSTRACT
A simple spectrophotometric method has been developed for simultaneous estimation of Montelukast Sodium and Ebastine from tablet dosage form. Absorbance correction method in which absorbance is measured at two wavelengths, 345 nm at which Ebastine has no absorbance and 253 nm at which both the drugs have considerable absorbance. This method was found linear between the range of 5-25 μg/ml for Montelukast Sodium and Ebastine. The accuracy and precision were determined and found to comply with ICH guidelines. This method showed good reproducibility and recovery with % RSD in the desired range. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Montelukast Sodium and Ebastine in their combined tablet dosage form.
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Patel, N. N., Rana, N. S., S, R. K., R.Patel, P., Limbachiya, U., & Pasha, T. Y. (2014). Spectrophotometric Method For Simultaneous Estimation of Montelukast Sodium and Ebastine in Bulk and Their Combined Tablet Dosage Form. Indian Journal of Pharmaceutical Education and Research, 48(2), 87–91. https://doi.org/10.5530/ijper.48.2.12