jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Evaluation of the Neuroprotective Effects of Centella asiatica Against Scopolamine Induced Cognitive Impairment in Mice

Sunanda BPV1, Latha K1, Rammohan B1, Uma Maheswari MS1, Surapaneni Krishna Mohan2★★ Corresponding author

  1. 1Department of Pharmacology, Karpagam Faculty of Medical Sciences and Research, Coimbatore – 641 032, Tamilnadu, India.
  2. 2Department of Biochemistry, Saveetha Medical College & Hospital, Faculty of Medicine, Saveetha University, Saveetha Nagar, Thandalam, Chennai – 602 105, Tamilnadu, India.

CORRESPONDENCE

Surapaneni Krishna Mohan

Department of Biochemistry, Saveetha Medical College & Hospital, Faculty of Medicine, Saveetha University, Saveetha Nagar, Thandalam, Chennai – 602 105, Tamilnadu, India.

krishnamohan.surapaneni@gmail.com

Received: 20-02-2014; Revised: 16-06-2014; Accepted: 03-09-2014.

Volume 48, Issue 4 · pp. 31–34 · PUBLISHED 2014 · DOI: 10.5530/ijper.48.4.5

View on IJPER original site ↗

ABSTRACT

Objective: This study was conducted to show Neuroprotective effect of aqueous extract of Centella asiatica in scopolamine induced cognitive impairment in mice. The improvement of cognitive impairment with Centella asiatica was compared against standard drug (Donepezil 50 μg/kg). Methods: Swiss albino mice (20–25 g) of either sex were randomly divided into 5 groups of 6 animals each. All the animals except the control group, received scopolamine (0.05 mg/kg) for 14 days. In day of 14th each animal was checked for cognitive impairment by using elevated plus maze (EPM). Dried powder of Centella asiatica (CA) was boiled with distilled water, cooled, filtered, placed on hotplate for complete evaporation, finally weighed and stored. The control group (Group1), scopolamine control (Group 2) test groups (CA-150 mg/kg as Group 3 & 300 mg/kg as Group 4) and standard drug (Group 5) received normal saline, Scopolamine, Centella asiatica (CA) extract (150 & 300 mg/kg + Scopolamine), donepezil (50 μg/kg) respectively by oral feeding. The Neuroprotective effect was assessed by elevated plus maze (EPM). Institutional Ethical Committee approval was obtained before the start of the study. Results: In elevated plus maze (EPM) models, it implies that Centella asiatica (CA) 300 mg/kg (group IV) significantly (p<0.001) decreases the retention transfer latency. Conclusion: The current study demonstrates statistically significant Neuroprotective activity of Centella asiatica (CA).

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    BPV, S., K, L., B, R., MS, U. M., & Mohan, S. K. (2014). Evaluation of the Neuroprotective Effects of Centella asiatica Against Scopolamine Induced Cognitive Impairment in Mice. Indian Journal of Pharmaceutical Education and Research, 48(4), 31–34. https://doi.org/10.5530/ijper.48.4.5