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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Synthesis and In vitro Cytotoxicity of a Novel Efficient Cisplatin-loaded Poly N-butyl Cyanoacrylate

Nahid Haghnazari1★, Hadi Mohammadi2, Mohammad Javad Mokhtari3, Changiz Karami4, Soheil Ghasemi5★ Corresponding author

  1. 1Department of biology, Faculty of Science, Sanandaj Branch, Islamic Azad University, Sanandaj-Iran.
  2. 2Young Researchers and Elite Club, Kermanshah Branch, Islamic Azad University, Kermanshah-Iran.
  3. 3Young Researchers and Elite Club, Zarghan Branch, Islamic Azad University, Zarghan-Iran.
  4. 4Department of Chemistry, Kermanshah Branch, Islamic Azad University, Kermanshah-Iran.
  5. 5Department of Pilot Nano biotechnology, Pasteur Institute of Iran, Tehran-Iran.

CORRESPONDENCE

Nahid Haghnazari

Department of biology, Faculty of Science, Sanandaj Branch, Islamic Azad University, Sanandaj-Iran.

n.haghnazari@gmail.com

Received: 11-03-2015; Revised: 25-05-2015; Accepted: 26-06-2015.

Volume 50, Issue 1 · pp. 190–197 · PUBLISHED 2016 · DOI: 10.5530/ijper.50.1.23

View on IJPER original site ↗

ABSTRACT

Purpose:Typically, drug-loaded polymer colloidal carriers are synthesized by the drug entrapment during anionic emulsion polymerization. The purpose of this study was to trial the ability of Cisplatin-loaded Poly Butyl Cyanoacrylate (PBCA) nanoparticles. Methods:The cytotoxicity of Cisplatin-loaded PBCA nanoparticles was evaluated by MT assay. The Polymeric nanoparticles have been characterized using TEM, SEM, FTIR and DLS. Results: Polymeric nanoparticles with loaded and unloaded drug prepared by this method, have spherical structure with 350 and 230 nm in diameter and their zeta potentials were -3.2 and -10.7 mv respectively. The average amount of drug loaded on the nanoparticles was 70.88 ± 5.51%. MTT assay was carried out to evaluate the cytotoxicity property of the nanoparticles. Inhibition concentration values (IC50 ) for Cisplatin-loaded Nanoparticles were 20.8 and 18.2 μM for 24 and 48 h respectively. Conclusion: It was shown that cisplatin-loaded nanoparticles strongly increased cytotoxicity in comparison to classic drug in the MCF-7 cell line.

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    Haghnazari, N., Mohammadi, H., Mokhtari, M. J., Karami, C., & Ghasemi, S. (2016). Synthesis and In vitro Cytotoxicity of a Novel Efficient Cisplatin-loaded Poly N-butyl Cyanoacrylate. Indian Journal of Pharmaceutical Education and Research, 50(1), 190–197. https://doi.org/10.5530/ijper.50.1.23