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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

A Diterpenoid Taxoquinone from Metasequoia glyptostroboides with Pharmacological Potential

Vivek Kumar Bajpai1, Irfan Ahmad Rather1, Sun Chul Kang2★, Yong-Ha Park1★★ Corresponding author

  1. 1Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbook 712-749, KOREA.
  2. 2Department of Biotechnology, College of Engineering, Daegu University, Gyeongsan, Gyeongbook 712-714, KOREA.

CORRESPONDENCE

Sun Chul Kang

Department of Biotechnology, College of Engineering, Daegu University, Gyeongsan, Gyeongbook 712-714, KOREA.

vbajpai04@yahoo

Received: 28-11-2015; Revised: 29-02-2016; Accepted: 05-03-2016.

Volume 50, Issue 3 · pp. 458–465 · PUBLISHED 2026 · DOI: 10.5530/ijper.50.3.20

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ABSTRACT

Background: The ubiquitin-proteasome pathway plays an important role in selective protein degradation and regulates multiple cellular processes, including cell cycle progression, proliferation and apoptosis. Cancer cells are more sensitive to the pro-apoptotic effects of proteasome inhibition than normal cells, hence, proteasome inhibitors can be used as novel anticancer drugs. Further, influenzacommonly known as “flu” is a contagious respiratory disease caused by sub-type of influenza A virus H1N1 which has resulted in enormous medical attention world-wide. Natural products are well known for their pharmacological potential in anticancer and antiviral therapies. Methods: In this study, an abietane-type diterpenoid, taxoquinone, isolated from Metasequoia glyptostroboides, was assessed for the first time for its therapeutic efficacy as a potential inhibitor of influenza A (H1N1) virus and 20S proteasomeusing cytopathic reduction assay and proteasome inhibition assay, respectively. Results: The taxoquinonedisplayed its anticancer effect in terms its ability to inhibit 20S human proteasome with IC50 value of 8.2 ± 2.4 µg/µL. Moreover, taxoquinone (500 µg/mL) displayed significant antiviral effect against H1N1 influenza virus in cytopathic reduction assay on MDCK cell line. Conclusion: These finding confirm pharmaceutical potential of taxoquinone as a novel therapeutic agent.

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    Bajpai, V. K., Rather, I. A., Kang, S. C., & Park, Y. (2026). A Diterpenoid Taxoquinone from Metasequoia glyptostroboides with Pharmacological Potential. Indian Journal of Pharmaceutical Education and Research, 50(3), 458–465. https://doi.org/10.5530/ijper.50.3.20