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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline

SahooJyotirmaya SahooJyotirmaya1★, SarangiPriyambadaKshirodaNandini SarangiPriyambadaKshirodaNandini2, PaidesettySudhirKumar PaidesettySudhirKumar3★ Corresponding author

  1. 1Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
  2. 2Departmentof Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
  3. 3Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Orissa, INDIA.

CORRESPONDENCE

SahooJyotirmaya SahooJyotirmaya

SahooJyotirmaya,Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.

jjyotisahoo@rediffmail.com

Received: 07-12-2016; Revised: 03-01-2017; Accepted: 15-02-2017.

Volume 51, Issue 3 · pp. 480–489 · PUBLISHED 2017 · DOI: 10.5530/ijper.51.3.76

View on IJPER original site ↗

ABSTRACT

Introduction: Novel Cu(II), Co(II) and Ni(II) complexes of 8-hydroxyquinolineazo analogues are synthesized from 5-((3-nitrophenyl)diazenyl) quinolin-8-ol (4a) and 5-((4-bromo-3- methylphenyl) diazenyl) quinolin-8-ol (4b). Methods: The structural environment and elemental composition of the synthesized metal complexes are confirmed by FT/IR, 1H NMR and CHNS/O elemental analyzer. The λmax and molecular mass are determined with the help of UV-visible and LC-MS spectrometer. Results: The magnetic susceptibility study suggested that the synthesized complexes are proposed with tetrahedral geometry. Among the six complexes, the bis bis 8, 8′ [5-((3-nitrophenyl) diazenyl) quinolinium] copper (4aLig2Cu) and bis 8, 8′ [5-((4-bromo-3-methylphenyl) diazenyl) quinolinium] copper (4bLig2Cu) showed significant antimicrobial activity. Conclusion: It was found that the metal complexes showed enhanced antimicrobial activity in comparison to their corresponding ligands.

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    SahooJyotirmaya, S., SarangiPriyambadaKshirodaNandini, S., & PaidesettySudhirKumar, P. (2017). In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline. Indian Journal of Pharmaceutical Education and Research, 51(3), 480–489. https://doi.org/10.5530/ijper.51.3.76