Article · Volume 51, Issue 3 · pp. 480–489
In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline
SahooJyotirmaya SahooJyotirmaya1, SarangiPriyambadaKshirodaNandini SarangiPriyambadaKshirodaNandini2, PaidesettySudhirKumar PaidesettySudhirKumar3
- 1Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
- 2Departmentof Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
- 3Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Orissa, INDIA.
Abstract
Introduction: Novel Cu(II), Co(II) and Ni(II) complexes of 8-hydroxyquinolineazo analogues are synthesized from 5-((3-nitrophenyl)diazenyl) quinolin-8-ol (4a) and 5-((4-bromo-3- methylphenyl) diazenyl) quinolin-8-ol (4b).Methods: The structural environment and elemental composition of the synthesized metal complexes are confirmed by FT/IR, 1H NMR and CHNS/O elemental analyzer. The λmax and molecular mass are determined with the help of UV-visible and LC-MS spectrometer.Results: The magnetic susceptibility study suggested that the synthesized complexes are proposed with tetrahedral geometry. Among the six complexes, the bis bis 8, 8′ [5-((3-nitrophenyl) diazenyl) quinolinium] copper (4aLig2Cu) and bis 8, 8′ [5-((4-bromo-3-methylphenyl) diazenyl) quinolinium] copper (4bLig2Cu) showed significant antimicrobial activity.Conclusion: It was found that the metal complexes showed enhanced antimicrobial activity in comparison to their corresponding ligands.
Keywords: Spectroscopic; Magnetic susceptibility; Antimicrobial; 8-Hydroxy quiniline; Antibiogram
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