The Effect of Aminophylline on Quinidine Passage into the Central Nervous System of Rats
Velibor Vasović1★, Nebojša Stilinović1, Saša Vukmirović1, Ivan Mikov2, Jelena Ćalasan3, Momir Mikov1★ Corresponding author
- 1Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, REPUBLIC OF SERBIA.
- 2Department of Occupational Medicine, Faculty of Medicine, University of Novi Sad, REPUBLIC OF SERBIA.
- 3Department of Nutrition and Immunology, Technische Universität München, Freising-Weihenstephan, GERMANY.
CORRESPONDENCE
Velibor Vasović
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, REPUBLIC OF SERBIA.
Received: 24-05-2017; Revised: 06-07-2017; Accepted: 10-01-2018.
Volume 52, Issue 1 · pp. 146–150 · PUBLISHED 2018 · DOI: 10.5530/ijper.52.1.16
ABSTRACT
Background and Objective: There is significant interest in mutual influence of substances during their passage into the central nervous system (CNS). Quinidine is a drug which can achieve significant concentration in CNS and cause side effects and aminophylline is a drug with possibility to change distribution of drugs in CNS. Thus the aim of this work was to study the effect of aminophylline on the transition of quinidine through the bloodbrain barrier into the central nervous system. Material and Methods: The experiments were carried out on Wistar rats, which received quinidine in the form of the retrograde intra-arterial bolus injection into the right axillary vein. The control group of animals received subcutaneously physiological solution 30 min before the intra-arterial quinidine application, whereas the test group animals also received subcutaneously aminophylline 30 min before quinidine application. The rats were sacrificed by decapitation in specified time intervals in order to determine quinidine concentration in different parts of CNS. Results: There were no significant changes in serum quinidine levels by comparing the results of experimental group with those of the control group of animals. In all parts of CNS aminophylline pre-treatment caused significant decrease in CNS quinidine concentration. Conclusion: The results suggest that co-administration of aminophylline and quinidine, decreases quinidine concentrations in the CNS of rats.
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Vasović, V., Stilinović, N., Vukmirović, S., Mikov, I., Ćalasan, J., & Mikov, M. (2018). The Effect of Aminophylline on Quinidine Passage into the Central Nervous System of Rats. Indian Journal of Pharmaceutical Education and Research, 52(1), 146–150. https://doi.org/10.5530/ijper.52.1.16