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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Pharmacokinetics and Tissue Distribution of PLGAPLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS

Yonglu Wang1★, Yang Li1, Jiwei Liu1,2, Xueming Li1★ Corresponding author

  1. 1College of Pharmacy, Nanjing Tech University CHINA.
  2. 2Nanjing Bestform Pharmaceutical Technology Co, Ltd CHINA.

CORRESPONDENCE

Yonglu Wang

College of Pharmacy, Nanjing Tech University CHINA.

wl_761107@163.com

Received: 26-05-2017; Revised: 06-07-2017; Accepted: 25-09-2017.

Volume 52, Issue 1 · pp. 42–53 · PUBLISHED 2018 · DOI: 10.5530/ijper.52.1.5

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ABSTRACT

Objective:A sensitive, rapid and reliable LC-MS/MS method was developed for simultaneously determination of daunorubicin (DNR) and tetrandrine (Tet) in rat plasma and tissues. Methods: The pharmacokinetics and tissue distribution of DNR/Tet-PLGAPLL-PEG-NPs-Tf (D/T-PPP-NPs-Tf), DNR/Tet-PLGA-PLL-PEG-NPs (D/T-PPP-NPs) and DNR/Tet (D/T) solution were compared following intravenous injection in the rats. Result: Compare to D/T solution, the parameters of DNR and Tet in D/T-PPP-NPs-Tf group presented significantly higher AUC (p<0.01) and lower V (p<0.05). Compared with D/T solution, the distribution of DNR in groups of D/T-PPP-NPs and D/T-PPP-NPs-Tf were higher in liver (p<0.01), lung (p<0.05), fat (p<0.05) and testicle (p<0.05), and were lower in heart, spleen, kidney (p<0.01), brain and intestine (p<0.01). The distribution of Tet in D/T-PPP-NPs and D/T-PPP-NPs-Tf groups were higher in liver, brain and uterus (p<0.05), and were lower in heart, spleen, lung, kidney and fat (p<0.05) compared with D/T solution. Conclusion: The LC-MS/MS method was specific, sensitive, rapid and reliable for the simultaneously determination of DNR and Tet in rat plasma and tissues. Compared with D/T solution, D/T-PPP-NPs-Tf tended to stay in the blood after injection. The distribution of D/T-PPP-NPs and D/T-PPP-NPs-Tf were significantly changed.

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    Wang, Y., Li, Y., Liu, J., & Li, X. (2018). Pharmacokinetics and Tissue Distribution of PLGAPLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS. Indian Journal of Pharmaceutical Education and Research, 52(1), 42–53. https://doi.org/10.5530/ijper.52.1.5