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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Chemo Preventive Effect of Rutin Against N-Nitrosodiethylamine-Induced and PhenobarbitalPromoted Hepatocellular Carcinoma in Wistar Rats

Yadala Prapurna Chandra1, A.H.M. Viswanathswamy1★★ Corresponding author

  1. 1K.L.E university‘s college of pharmacy, Vidayanagar, Hubli-580031, Karnataka, INDIA.

CORRESPONDENCE

A.H.M. Viswanathswamy

K.L.E university‘s college of pharmacy, Vidayanagar, Hubli-580031, Karnataka, INDIA.

vmhiremath2004@ gmail.com

Received: 25-02-2017; Revised: 26-05-2017; Accepted: 29-09-2017.

Volume 52, Issue 1 · pp. 78–86 · PUBLISHED 2018 · DOI: 10.5530/ijper.52.1.9

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ABSTRACT

Background: In recent years, a large number of natural compounds have been identified and proved to have a potential cancer chemopreventive importance due to their strong antioxidant and cytotoxic activities. Objective: The present study is designed to investigate the preventive effects of Rutin against N-Nitrosodiethylamine-induced and Phenobarbital-promoted Hepatocellular carcinoma in male wistar rats. Materials and Methods: Twenty-four male wistar rats were divided into four groups (n=6). Group I serve as Control, Group II was induced HCC by DEN (200mg/kg b.wt) followed by phenobarbital (0.05 % w/v), Group III received same as Group II and followed by Rutin (50mg/kg b.wt) and Group IV received Rutin alone at a dose of 50mg/kg b.wt, up to 16 successive weeks. Results: Results observed that there is significant increase in relative liver weight and liver marker enzymes (P<0.001), tumor marker enzymes (AFP, CEA at P<0.001) and also Significant abnormalities were observed in membrane bound enzymes and Electrolytes, whereas the above said alterations were significantly restored in Rutin treated group compared with DEN treated Group. Conclusion: The results of these findings suggested that Rutin can be used as an adjunct to conventional chemopreventive agent, which may provide a novel therapeutic approach to serve as a promising agent for treatment of Hepatocellular carcinoma.

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    Chandra, Y. P., & Viswanathswamy, A. (2018). Chemo Preventive Effect of Rutin Against N-Nitrosodiethylamine-Induced and PhenobarbitalPromoted Hepatocellular Carcinoma in Wistar Rats. Indian Journal of Pharmaceutical Education and Research, 52(1), 78–86. https://doi.org/10.5530/ijper.52.1.9