Factorial Design Methodology for Development of Pediatric Nasal Spray: Study on Xylometazoline Nasal Solution Used For Treatment of Nasal Congestion
Falgun Bhuva1★, L D Patel1, Krutagn Patel1★ Corresponding author
- 1Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat -387001, India.
CORRESPONDENCE
Falgun Bhuva
Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat -387001, India.
Received: 03-08-2016; Revised: 17-11-2016; Accepted: 23-11-2016.
Volume 52, Issue 2 · pp. 218–229 · PUBLISHED 2018 · DOI: 10.5530/ijper.52.2.25
ABSTRACT
Objective:The objective of the present work is to develop the meter dose pediatric formulation of xylometazoline hydrochloride for enhanced effectiveness for nasal decongestion. Experimental Work: The 32 factorial experimental design was employed for optimization of sodium cholate (X1 ) and Polyethyleneglycol 400 concentration (X2 ) in the formulation. The optimized formulation contains 1.18 % w/v sodium cholate and 13 % v/v Polyethyleneglycol 400. The formulation was further evaluated for its drug content, pH, viscosity, spray content uniformity, In vitro-diffusion studies, pump delivery, spray pattern, sterility and stability study. Results: The percentage diffusion and viscosity was observed 91.33 ± 1.15 % and 19.33 ± 0.57 centipoise respectively. The meter dose nasal formulation shows the superior performance during in-vitro drug release compared with current marketed formulations, which provides alternative option for treatment of nasal decongestion
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Bhuva, F., Patel, L. D., & Patel, K. (2018). Factorial Design Methodology for Development of Pediatric Nasal Spray: Study on Xylometazoline Nasal Solution Used For Treatment of Nasal Congestion. Indian Journal of Pharmaceutical Education and Research, 52(2), 218–229. https://doi.org/10.5530/ijper.52.2.25