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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Formulation and Evaluation of Oral Fast Dissolving Films of Poorly Soluble Drug Ezetimibe Using Transcutol Hp

Pondugula Sudhakara Reddy1, KV Ramana Murthy2★★ Corresponding author

  1. 1Star “A” apartments, Bhagyanagar colony, Kukatpally, Hyderabad, Telangana 500072, INDIA.
  2. 2Professor of Pharmaceutics, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, Andhra Pradesh, INDIA.

CORRESPONDENCE

KV Ramana Murthy

Professor of Pharmaceutics, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, Andhra Pradesh, INDIA.

sudhakarpharma@gmail.com

Received: 14-09-2017; Revised: 08-11-2017; Accepted: 26-11-2017.

Volume 52, Issue 3 · pp. 398–407 · PUBLISHED 2018 · DOI: 10.5530/ijper.52.3.46

View on IJPER original site ↗

ABSTRACT

Introduction: The objective of the present formulation research is to deliver the drugs at a faster rate and to provide immediate onset of action in a shorter period of time with improved bioavailability. Materials and Methods: Ezetimibe, a gift sample from Lupin Ltd., Pune, Transcutol HP, a gift sample from Gattefosse India Pvt. Ltd., Goa., HPMC E5, HPMC E6, HPMC E15 are gift samples from Colorcon India Pvt. Ltd. Results and Discussion: Among prepared formulations coded E1 to E20, formulation E6 was shown promising results, hence further studies done without transcutol HP and documented clear results saying that, without transcutol HP has shown around 50% of drug even after 90 min of time, whereas within 10 min complete drug release observed with transcutol HP formulation. Conclusion: The study clearly indicated the influence of transcutol HP in enhancing the solubility of the poorly soluble drugs as the films made without transcutol HP failed to give the desired release characteristics within 10 min.

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    Reddy, P. S., & Murthy, K. R. (2018). Formulation and Evaluation of Oral Fast Dissolving Films of Poorly Soluble Drug Ezetimibe Using Transcutol Hp. Indian Journal of Pharmaceutical Education and Research, 52(3), 398–407. https://doi.org/10.5530/ijper.52.3.46