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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Antiparasitic Efficacy of Artemisia ludoviciana Nutt. (Asteraceae) Essential Oil for Acanthamoeba castellanii, Leishmania infantum and Trichomonas vaginalis

Ayşe Baldemir1★, Ülkü Karaman2, Selen İlgün1, Gamze Kaçmaz2, Betül Demirci3★ Corresponding author

  1. 1Erciyes University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Kayseri, TURKEY.
  2. 2Ordu University, Faculty of Medicine, Department of Medical Parasitology, Ordu, TURKEY.
  3. 3Anadolu University, Faculty of Pharmacy, Department of Pharmacognosy, Eskişehir, TURKEY.

CORRESPONDENCE

Ayşe Baldemir

Erciyes University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Kayseri, TURKEY.

aysebaldemir@gmail.com

Received: 18-08-2017; Revised: 12-10-2017; Accepted: 29-10-2017.

Volume 52, Issue 3 · pp. 416–425 · PUBLISHED 2018 · DOI: 10.5530/ijper.52.3.48

View on IJPER original site ↗

ABSTRACT

Background: Artemisia ludoviciana Nutt. (Asteraceae) is an aromatic, herbaceous, perennial plant and known commonly name as “White Sage”, “Black Sage”, “Prairie Sage” or “Cudweed Sagewort”. It is traditionally used as an antispasmodic, anthelminthic, antidiarrhoeal, stomachic, hepatic colic, appetizer, and regulator of menstruation, antimalaric and antiparasitic efficiancy. Objective: The essential oil composition of the flowering herb of A. ludoviciana (AL) was investigated and for the first time, the oil was screened for antiparasitic activity. Methods: The chemical composition of the hydrodistilled essential oil (EO) obtained from the herb with flowered of A. ludoviciana was analyzed by Gas Chromatography–Flame Ionization Detector (GC-FID) and Gas Chromatography–Mass Spectrometry (GC-MS). Results and Discussion: The outcomes showed that the major components of oil were camphor (40.6%), 1,8-cineole (25.5%) and camphene (4.7%), among 45 identified compounds, comprising 98.5 of the total oil. In addition, the oil was tested against Acanthamoeba castellanii, Leishmania infantum and Trichomonas vaginalis. Conclusion: In this study, it is first demonstrated that A. ludoviciana essential oil (AL-EO) is effective against three important parasites.

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    Baldemir, A., Karaman, Ü., İlgün, S., Kaçmaz, G., & Demirci, B. (2018). Antiparasitic Efficacy of Artemisia ludoviciana Nutt. (Asteraceae) Essential Oil for Acanthamoeba castellanii, Leishmania infantum and Trichomonas vaginalis. Indian Journal of Pharmaceutical Education and Research, 52(3), 416–425. https://doi.org/10.5530/ijper.52.3.48