Alcohol Extract of Wattakaka volubilis (L.F) Stapf Root Inhibits Aldose Reductase to Prevent Diabetes Associated Cataract Formation in Rats
Hajira Banu Haroon1, Anita Murali1★★ Corresponding author
- 1Department of Pharmacology, Faculty of.
Received: 11-07-2018; Revised: 29-09-2018; Accepted: 29-12-2018.
Volume 53, Issue 2 · pp. 261–267 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.2.34
ABSTRACT
Aim: The aim of this study was to investigate the aldose reductase inhibition and anti-cataract property of W. volubilis root extract in rats with streptozotocin induced diabetes mellitus. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin at the dose of 45 mg/kg. Diabetic animals were treated with glimepiride (0.5 mg/kg) and alcohol extract at 100 and 200 mg/kg for 38 d. Lens were isolated and certain markers were estimated. Results: Treatment of diabetic animals with alcohol extract of W. volubilis root inhibited aldose reductase activity (p < 0.001) and sorbitol formation in the lens. Additionally, a reduction in the levels of MDA, GSH, SDH and LDH in extract treated groups was observed. There was an overall decrease in the severity of cataract progression. Conclusion: The result provided evidence that alcohol extract of W. volubilis root prevents the development of diabetic cataract in rats.
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Haroon, H. B., & Murali, A. (2019). Alcohol Extract of Wattakaka volubilis (L.F) Stapf Root Inhibits Aldose Reductase to Prevent Diabetes Associated Cataract Formation in Rats. Indian Journal of Pharmaceutical Education and Research, 53(2), 261–267. https://doi.org/10.5530/ijper.53.2.34