Article · Volume 53, Issue 4 · pp. 670–674
In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations
Muhammad Torequl Islam1,2, Shamim Molla3, Apu Kumar Das3, Farhana Zaman3, Md. Roich Khan3
- 1Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
- 2Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
- 3Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, BANGLADESH.
Abstract
Background: Black seed oil and Phytol (PHY) are evident for their promising biological effects in various test systems.Aim: This study evaluates anti-atherothrombosis activity of Nigella sativa oil (NSO) and Phytol (PHY).Materials and Methods: The clotlysis activity of the NSO and/or PHY has been investigated by taking Streptokinase (SK) as a standard clotlysis drug.Results: The results suggest that the NSO and PHY exhibited a concentration-dependent clotlysis activity in human clotted blood. The highest clotlysis of the NSO and PHY was seen by 57.83 ± 0.23% and 53.05 ± 2.93% with 80 µL and 150 µg per tube, respectively. NSO co-treated with PHY showed a better clotlysis capacity than the NSO and PHY. The vehicle showed negligible clotlysis (2.86 ± 4.33%) capacity, while the standard SK (100 I.U.) showed 78.96 ± 1.08% clotlysis activity.Conclusion: NSO and/or PHY exhibited clotlysis activity in human clotted blood in in vitro.
Keywords: Nigella sativa oil; Phytol; Antioxidant; Atherothrombosis; Cardiovascular; diseases
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