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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations

Muhammad Torequl Islam1,2★, Shamim Molla3, Apu Kumar Das3, Farhana Zaman3, Md. Roich Khan3★ Corresponding author

  1. 1Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
  2. 2Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
  3. 3Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, BANGLADESH.

CORRESPONDENCE

Muhammad Torequl Islam

Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.

muhammad.torequl.islam@tdtu.edu.vn

Received: 22-02-2019; Revised: 17-05-2019; Accepted: 04-09-2019.

Volume 53, Issue 4 · pp. 670–674 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.4.129

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ABSTRACT

Background: Black seed oil and Phytol (PHY) are evident for their promising biological effects in various test systems. Aim: This study evaluates anti-atherothrombosis activity of Nigella sativa oil (NSO) and Phytol (PHY). Materials and Methods: The clotlysis activity of the NSO and/or PHY has been investigated by taking Streptokinase (SK) as a standard clotlysis drug. Results: The results suggest that the NSO and PHY exhibited a concentration-dependent clotlysis activity in human clotted blood. The highest clotlysis of the NSO and PHY was seen by 57.83 ± 0.23% and 53.05 ± 2.93% with 80 µL and 150 µg per tube, respectively. NSO co-treated with PHY showed a better clotlysis capacity than the NSO and PHY. The vehicle showed negligible clotlysis (2.86 ± 4.33%) capacity, while the standard SK (100 I.U.) showed 78.96 ± 1.08% clotlysis activity. Conclusion: NSO and/or PHY exhibited clotlysis activity in human clotted blood in in vitro.

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    Islam, M. T., Molla, S., Das, A. K., Zaman, F., & Khan, M. R. (2019). In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations. Indian Journal of Pharmaceutical Education and Research, 53(4), 670–674. https://doi.org/10.5530/ijper.53.4.129