jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Role of Testosterone in Swimming Exercise-induced Analgesia in Rats

Dheeraj Kumar Sharma1★, Niraj Kumar Singh2, Ahsas Goyal2, Jeetendra Kumar Gupta2, Harlokesh Narayan Yadav3★ Corresponding author

  1. 1SGT College of Pharmacy, SGT University, Gurugram, Haryana, INDIA.
  2. 2Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.
  3. 3All India Institute of Medical Sciences, Gautam Nagar, Ansari Nagar East, New Delhi, INDIA.

CORRESPONDENCE

Dheeraj Kumar Sharma

SGT College of Pharmacy, SGT University, Gurugram, Haryana, INDIA.

sharmadk33@gmail.com

Received: 27-02-2019; Revised: 17-05-2019; Accepted: 26-07-2019.

Volume 53, Issue 4 · pp. 675–681 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.4.130

View on IJPER original site ↗

ABSTRACT

Objective:“Feel good effect” of exercise is well known. Activation of pain inhibitory mechanisms after exercise is also well documented. Swimming is considered as a beneficial exercise as well as health-promoting sport. The significance of testosterone in swimming exercise-induced analgesia is yet to be understood. Therefore, it is worthwhile to investigate the significance of testosterone in swimming exercise-induced analgesia. Materials and Methods: The basal tail flick latencies of all animals were recorded by using tail flick analgesiometer. In order to observe the effect of testosterone on swimming exercise-induced analgesia, testicles of animals of some groups were surgically removed. Then animals were subjected to swimming sessions of different patterns. After swimming, tail flick latencies were measured. Results: Swimming sessions resulted in increase in pain thresholds of all animals. Castration negatively affected the degree of analgesia achieved in rats. However, daily treatment of testosterone propionate (500µg/kg, s.c.) improved swim-induced analgesia in castrated rats. Moreover, daily administration of naloxone hydrochloride (1mg/kg, i.p.) fifteen min prior to swimming suppressed testosterone therapy resulted in an increase in swim-induced analgesia in castrated animals. Conclusion: We concluded that testosterone plays a significant role in swimming exercise-induced analgesia in male Wistar albino rats and this positive effect of testosterone on pain threshold might be mediated through its probable effect on the endogenous opioid system.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sharma, D. K., Singh, N. K., Goyal, A., Gupta, J. K., & Yadav, H. N. (2019). Role of Testosterone in Swimming Exercise-induced Analgesia in Rats. Indian Journal of Pharmaceutical Education and Research, 53(4), 675–681. https://doi.org/10.5530/ijper.53.4.130