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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Characterization of Thermal Fraction of Clarified Butter and its Applicability to Improve Bioavailability of Rosuvastatin

Vijendra Kumar Suryawanshi1, Suhas Narayan Sakarkar2★, Chanchal Deep Kaur1, Khomendra Kumar Sarwa3★ Corresponding author

  1. 1Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, INDIA.
  2. 2School of Pharmacy, GH Raisoni University, Village-Dhoda Borgaon, Saikheda Dist. Chhindwara, Madhya Pradesh, INDIA.
  3. 3Department of Pharmacy, Government Girl’s Polytechnic, Raipur, Chhattisgarh, INDIA.

CORRESPONDENCE

Suhas Narayan Sakarkar

School of Pharmacy, GH Raisoni University, Village-Dhoda Borgaon, Saikheda Dist. Chhindwara, Madhya Pradesh, INDIA.

snsakarkar@gmail.com

Received: 17-03-2019; Revised: 17-05-2019; Accepted: 04-09-2019.

Volume 53, Issue 4 · pp. 716–723 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.4.136

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ABSTRACT

Aim: The present investigation shows confirmatory evidence for the complex formation of Rosuvastatin with a fraction of Clarified Butter. Materials and Methods: Fractions of Clarified Butter prepared according to thermal behavior at different temperatures (30°C, 40°C, 50°C). Rosuvastatin biform complex with Clarified Butter in the ratio (1:1) and (1:2) w/w were prepared. Physicochemical properties of all fractions of Clarified Butter was determined as per Indian Pharmacopoeia. The fractions were subject to Fouriertransform Infrared spectroscopy (FTIR), Differential Scanning Calorimeters (DSC) and invitro release studies (Simulated gastric fluid, pH 1.2 for 2 h and simulated intestinal fluid, pH 6.8 for 6 h). Results: Based on these investigations; the optimized ratio (1:1) w/w were further characterized for DSC and FTIR studies. Where Rosuvastatin exhibited a strong carbonyl band at 1543.05 cm−1 , all fractions showed the disappearance of strong carbonyl band at 1543.05 cm−1, spectra of biform complex shifted to higher frequency 1747.51 cm−1 (13.29 % increase), that confirmed carboxylic and hydroxyl group of both saturated and unsaturated fatty acid present in Clarified Butter. From in vitro release study the highest percent release i.e. 99.23±0.08% of Rosuvastatin was obtained from 1:1 biform complex. DSC thermogram revealed the formation of eutectic mixture by lowering the peak of pure Clarified Butter (67.4°C) to 58.10°C due to the formation of biform complex. Conclusion: Thus, Clarified Butter and its fraction illustrated enhanced bioavailability of Rosuvastatin.

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    Suryawanshi, V. K., Sakarkar, S. N., Kaur, C. D., & Sarwa, K. K. (2019). Characterization of Thermal Fraction of Clarified Butter and its Applicability to Improve Bioavailability of Rosuvastatin. Indian Journal of Pharmaceutical Education and Research, 53(4), 716–723. https://doi.org/10.5530/ijper.53.4.136