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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Pro-Argin Technology Based Formulation of Eugenol Containing Toothpaste

Dhanashri Dhananjay Shete1, Minakshi Arun Patmas1★, Shriniwas Pramod Patil1★ Corresponding author

  1. 1Department of Pharmacognosy, SCES’s Indira College of Pharmacy, Tathawade, Pune, Maharashtra, INDIA.

CORRESPONDENCE

Minakshi Arun Patmas

Department of Pharmacognosy, SCES’s Indira College of Pharmacy, Tathawade, Pune, Maharashtra, INDIA.

minakshipatmas@gmail.com

Received: 16-08-2019; Revised: 26-11-2019; Accepted: 10-01-2020.

Volume 54, Issue 2 · pp. 323–328 · PUBLISHED 2020 · DOI: 10.5530/ijper.54.2.37

View on IJPER original site ↗

ABSTRACT

Introduction: Formation of cavities and hyper sensitivity are few dental problems, manifested by dental pain. Since long back, volatile oil present in clove buds (Myrtaceae) have been used as dental analgesic. Various toothpastes containing clove oil are marketed. Eugenol is chemically, terpenoids, active principle present in clove oil. It has several pharmacological potentials. Pro-argin technology is novel approach for formulation of toothpaste with arginine (8%) and calcium carbonate. Aim: This research was aimed towards formulation of toothpaste containing eugenol by Pro-argin technology and its evaluation. Materials and Methods: Toothpaste containing eugenol was formulated with arginine (8%) and calcium carbonate by simple trituration. Formulation was then evaluated for various parameters like pH, spreadability, foaming ability, content determination and also analysed for texture. Results and Discussion: On formulation, brownish, aromatic fragrant toothpaste was obtained with acceptable pH, spreadability and foaming ability. About 92.48% of eugenol content of added quantity was determined. Conclusion: Eugenol can successfully be formulated in toothpaste by Pro-Argin approach. More than 90% content determination would facilitate maximum release of added eugenol.

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    Shete, D. D., Patmas, M. A., & Patil, S. P. (2020). Pro-Argin Technology Based Formulation of Eugenol Containing Toothpaste. Indian Journal of Pharmaceutical Education and Research, 54(2), 323–328. https://doi.org/10.5530/ijper.54.2.37