Article · Volume 55, Issue 1S · pp. S56–S65

Solubility Enhancement of Oxcarbazepine by Melt Sonocrystallization Technique to Increase the Bioavailability

Vinayak Shivamurthy Mastiholimath¹, Gauri Pradeep Mashelkar¹, Vinodkumar Shirshalappa Mannur¹, Panchaxari Mallappa Dandagi², Pukar Khanal³

¹Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, INDIA.
²Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, INDIA.
³Department of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, INDIA.

Abstract

Objectives: The present study aimed to enhance the solubility of Oxcarbazepine by melt sono crystallization technique as well as increase its bioavailability.Materials and Methods: Tablets of Melt Sonocrystallized Oxcarbazepine were prepared by the direct compression method. Compression was performed on a Remik mini-press tablet compression machine using an 8mm punch. The analytical method development was carried out in 20x10 and 10x10 twin trough chambers. The sample was spotted with a 100μl camas microliter syringe on silica gel aluminum plate 60 F254 (20X10) and (10x10) plate; Merck using a CAMAG Linomat-5 sample applicator.Results: The Oxcarbazepine had better solubility in the ph 6.8 buffer. The mobile phase selected for HPTLC was Ethyl acetate: Methanol in the ratio (8:2 v/v) with the Rf value 0.582. The formulation F2 containing 5% SSG showed a release of 90.51% and was considered as an optimized formulation based on several parameters such as friability (0.21%), disintegration time(27.8 sec) and in vitro dissolution studies.

Keywords: Melt sonocrystallized; Oxcarbazepine; Method development; HPTLC; Validation; Solubility Enhancement

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