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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Solubility Enhancement of Oxcarbazepine by Melt Sonocrystallization Technique to Increase the Bioavailability

Vinayak Shivamurthy Mastiholimath1★, Gauri Pradeep Mashelkar1, Vinodkumar Shirshalappa Mannur1, Panchaxari Mallappa Dandagi2, Pukar Khanal3★ Corresponding author

  1. 1Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, INDIA.
  2. 2Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, INDIA.
  3. 3Department of Pharmacology, KLE College of Pharmacy, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, INDIA.

CORRESPONDENCE

Vinayak Shivamurthy Mastiholimath

Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, INDIA.

mastiholimath@rediffmail.com

Received: 14-09-2020; Revised: 23-11-2020; Accepted: 08-02-2021.

Volume 55, Issue 1S · pp. S56–S65 · PUBLISHED 2021 · DOI: 10.5530/ijper.55.1s.37

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ABSTRACT

Objectives: The present study aimed to enhance the solubility of Oxcarbazepine by melt sono crystallization technique as well as increase its bioavailability. Materials and Methods: Tablets of Melt Sonocrystallized Oxcarbazepine were prepared by the direct compression method. Compression was performed on a Remik mini-press tablet compression machine using an 8mm punch. The analytical method development was carried out in 20x10 and 10x10 twin trough chambers. The sample was spotted with a 100μl camas microliter syringe on silica gel aluminum plate 60 F254 (20X10) and (10x10) plate; Merck using a CAMAG Linomat-5 sample applicator. Results: The Oxcarbazepine had better solubility in the ph 6.8 buffer. The mobile phase selected for HPTLC was Ethyl acetate: Methanol in the ratio (8:2 v/v) with the Rf value 0.582. The formulation F2 containing 5% SSG showed a release of 90.51% and was considered as an optimized formulation based on several parameters such as friability (0.21%), disintegration time(27.8 sec) and in vitro dissolution studies.

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    Mastiholimath, V. S., Mashelkar, G. P., Mannur, V. S., Dandagi, P. M., & Khanal, P. (2021). Solubility Enhancement of Oxcarbazepine by Melt Sonocrystallization Technique to Increase the Bioavailability. Indian Journal of Pharmaceutical Education and Research, 55(1S), S56–S65. https://doi.org/10.5530/ijper.55.1s.37