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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

Saadet Belhan1★, Ahmet Ufuk Kömüroğlu2, Uğur Özdek2, Ali Sefa Mendil3, Ali Rıza Kul2, Muhammed Bahaeddin Dörtbudak4, Arzu Gezer2★ Corresponding author

  1. 1Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Van Yuzuncu Yıl University, Van, TURKEY.
  2. 2Vocational School of Health Services, Van Yuzuncu Yıl University, Van, TURKEY.
  3. 3Department of Pathology, Faculty of Veterinary, Erciyes University, Kayseri, TURKEY.
  4. 4Department of Pathology, Faculty of Veterinary Faculty, Atatürk University, Erzurum, TURKEY.

CORRESPONDENCE

Saadet Belhan

Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Van Yuzuncu Yıl University, Van, TURKEY.

saadetkaratas@hotmail.com

Received: 06-08-2020; Revised: 02-12-2020; Accepted: 01-03-2021.

Volume 55, Issue 2 · pp. 544–549 · PUBLISHED 2021 · DOI: 10.5530/ijper.55.2.92

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ABSTRACT

Background: The present study aims to investigate the effects of calcium fructoborate on testicular DNA damage and testicular tissue biochemical markers and serum testosterone levels after cadmium chloride administration. Materials and Methods: 28 Wistar albino rats (200-220 g) in the study were divided into 4 groups with an equal number. These groups are; Control group (No chemicals applied), calcium fructoborate (100 mg) group, Cadmium chloride (200 mg/L) + calcium fructoborate (100 mg), Cadmium chloride (200 mg/L) group. The study lasted 28 days and both chemicals were applied daily with oral gavage. Results: While 8-hydroxy-2-deoxyguanosine (8-OHdG) expression was moderate in the cadmium chloride + calcium fructoborate group, the expression in the cadmium chloride group was severe. In the cadmium chloride group, testicular tissue glutathione (GSH) and 8-OHdG levels, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and serum testosterone levels were significantly decreased compared to other groups. It is determined that the reversal of the change in the parameters listed in the calcium fructoborate group. Conclusion: The reversal of the change in the parameters listed in the calcium fructoborate group indicates the positive strength of the present chemical. It is our suggestion to transfer calcium fructoborate into life practice by conducting further clinical studies and evaluating different parameters.

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    Belhan, S., Kömüroğlu, A. U., Özdek, U., Mendil, A. S., Kul, A. R., Dörtbudak, M. B., & Gezer, A. (2021). Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity. Indian Journal of Pharmaceutical Education and Research, 55(2), 544–549. https://doi.org/10.5530/ijper.55.2.92