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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate

Sagar Kumar Mohapatra1, Rudra Narayan Sahoo1,2, Subrata Mallick1, Rajaram Mohapatra1★★ Corresponding author

  1. 1Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA.
  2. 2School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, INDIA.

CORRESPONDENCE

Rajaram Mohapatra

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan, (Deemed to be University), Bhubaneswar-751003, Odisha, INDIA.

rajaram.liku@gmail.com

Received: 26-02-2021; Revised: 10-04-2021; Accepted: 02-07-2021.

Volume 55, Issue 3 · pp. 677–684 · PUBLISHED 2021 · DOI: 10.5530/ijper.55.3.139

View on IJPER original site ↗

ABSTRACT

Purpose: Oral drug delivery system has always been a preferred choice for the treatment of peptic ulcer and gastroesophageal reflux diseases. Being a proton pump inhibitor omeprazole restricts gastric acid secretion but the foremost downside is its degradation in acidic environments. The systemic absorption of gastro-unstable drugs can be improved by the enteric coating. Materials and Methods: This study was aimed at developing an effective enteric coating for omeprazole tablets using HPMC E5-LV and Hydroxypropyl Methylcellulose Acetate Succinate (HPMC-AS) polymers. The core tablets were subcoated with HPMC E5-LV which acted as a barrier between core tablet and enteric coated tablet. The enteric coating was applied using HPMC-AS. Results: Dissolution information unveiled that the enteric coat remained in place for 2 hr in acidic medium (0.1N HCl) and later dissolved when came in contact with basic media (acetate buffer pH 6.8), it dissolved within a jiffy. Conclusion: The release profile showed 91 to 98% drug release within 1hr in pH 6.8 Acetate buffer. Further instrumental analysis was performed to ascertain drug-polymer interaction.

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    Mohapatra, S. K., Sahoo, R. N., Mallick, S., & Mohapatra, R. (2021). Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate. Indian Journal of Pharmaceutical Education and Research, 55(3), 677–684. https://doi.org/10.5530/ijper.55.3.139