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Indian Journal of Pharmaceutical Education and ResearchNOW IN
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Formulation of Silk Fibroin-based Single Polymeric Floating Microspheres for Sustained Release of Lafutidine

JidnyasaPantwalawalkar JidnyasaPantwalawalkar1, SopanNangare SopanNangare2★★ Corresponding author

  1. 1Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, INDIA.
  2. 2Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, INDIA.

CORRESPONDENCE

SopanNangare SopanNangare

SopanNangare,Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, INDIA.

snangareopan@gmail.com

Received: 23-05-2021; Revised: 09-01-2022; Accepted: 28-01-2022.

Volume 56, Issue 2 · pp. 396–404 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.2.59

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ABSTRACT

Purpose:The present study was aimed at the formulation of lafutidine-loaded silk fibroinbased floating microspheres (LAFU-SF-Microspheres) for the site-specific sustained release of the drug. Materials and Methods: Briefly, the single polymeric system comprising SF was selected to prepare LAFU-SF-Microspheres by employing the emulsion solvent evaporation method. Subsequently, the obtained LAFU-SF-Microspheres were assessed for particle size, zeta potential, percent entrapment efficiency (%EE), percentage drug content (%DC), micromeritics, floating profile, in-vitro drug release, spectroscopical analysis, and accelerated stability study. Results: The particle size and zeta potential of the LAFU-SF-Microsphere were found to be 2.3-6.8μm and -21.93mV respectively whilst % EE and % DC of LAFU-SF-Microspheres were found to be 86.83±3.46% and 93.89±3.98% respectively. Moreover, it demonstrated the adequate angle of repose (26.50±1.06°) and Carr’s Compressibility Index (CI) confirming the excellent flow properties. In view of the floating profile, LAFU-SF-Microspheres showed floating lag time (FLT) between 9-13sec and total floating time (TFT) more than 12hr. Moreover, the % buoyancy was found to be 97.62± 4.78%. LAFU-SF-Microspheres showed in-vitro % drug release up to 92.41±4.29% adopting the first-order model. The FTIR indicated successful incorporation of LAFU in LAFU-SF-Microspheres. The DSC and PXRD indicated the disrupted crystallinity of LAFU in LAFU-SF-Microspheres. The SEM images of microspheres displayed spherical shapes with smooth textures. Conclusion: SF microspheres can be fruitfully applied for customized floating and release patterns of drugs with distinct solubility classes.

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    JidnyasaPantwalawalkar, J., & SopanNangare, S. (2022). Formulation of Silk Fibroin-based Single Polymeric Floating Microspheres for Sustained Release of Lafutidine. Indian Journal of Pharmaceutical Education and Research, 56(2), 396–404. https://doi.org/10.5530/ijper.56.2.59