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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Formulation and Evaluation of Bendamustine Loaded Polymeric Nanoparticle

Mallikarjun Telsang1★, Pradeep D2★, Wilson B3, Vasia Tamreen4, Shaik Sadik5, Mohammed Habeebuddin6, Afzal Haq Asif7, Mohammed Basheeruddin Asdaq8, Sree Harsha Nagaraja9,10, Syed Dawood Noor11★ Corresponding author

  1. 1Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  2. 2Department of Pharmaceutics, IKON Pharmacy College, Bidadi, Karnataka, INDIA.
  3. 3Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, INDIA.
  4. 4Department of Pharmaceutics, Oxbridge College of Pharmacy, Bengaluru, Karnataka, INDIA.
  5. 5Department of Pharmacology, Oxbridge College of Pharmacy, Bengaluru, Karnataka, INDIA.
  6. 6Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  7. 7Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  8. 8Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, SAUDI ARABIA.
  9. 9Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Hofuf, Al-Ahsa, SAUDI ARABIA.
  10. 10Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
  11. 11Department of Pharmacognosy, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.

CORRESPONDENCE

Mallikarjun Telsang

Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.

mvtelsang@kfu.edu.sa

Received: 04-10-2021; Revised: 22-01-2022; Accepted: 23-02-2022.

Volume 56, Issue 2 · pp. 414–419 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.2.61

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ABSTRACT

Background: Bendamustine-loaded albumin nanoparticles were prepared using different concentrations of Bovine Serum Albumin (BSA) with the goal of delivering the medication to particular cancer cells. Materials and Procedures:The nanoparticles were prepared using simple coacervation technique with increasing concentrations of BSA. The nanoparticles were characterized for process yield, particle size, surface morphology, drug loading capacity (%), particle size distribution (Polydispersity index), in-vitro drug release. The drug release kinetics were studies using different dissolution models. The drug loading capacity of the produced nanoparticles varied from 10.4% to 19%. Formulation (F1) had a mean particle size of approximately 122.4 nm and polydispersivity index of 0.432 across the different compositions. Bendamustine nanoparticles exhibit sustained drug release with almost 51.8% bendamustine released in one day. The drug release kinetics follows Korsmeyer-Peppas model with a Fickian drug release mechanism. The Bendamustine nanoparticles were found to be stable for a month at 40±5C and 75±5% relative humidity. Conclusion: Bendamustine loaded BSA nanoparticles were developed which were found to exhibit a sustained drug release profile. Albumin based Bendamustine nanoparticles have the potential to be explored further for the better management of the cancer chemotherapy with reduced side effects.

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    Telsang, M., D, P., B, W., Tamreen, V., Sadik, S., Habeebuddin, M., Asif, A. H., Asdaq, M. B., Nagaraja, S. H., & Noor, S. D. (2022). Formulation and Evaluation of Bendamustine Loaded Polymeric Nanoparticle. Indian Journal of Pharmaceutical Education and Research, 56(2), 414–419. https://doi.org/10.5530/ijper.56.2.61