Dose Conversion Between Animals and Humans: A Practical Solution
Shery Jacob1★, Anroop B Nair2, Mohamed A Morsy2,3★ Corresponding author
- 1Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, UAE.
- 2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 3Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia, EGYPT.
CORRESPONDENCE
Shery Jacob
Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, UAE.
Received: 24-04-2022; Revised: 12-05-2022; Accepted: 01-06-2022.
Volume 56, Issue 3 · pp. 600–607 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.3.108
ABSTRACT
Selecting the most appropriate first-in-human and pharmacologically active dose for any new drugs or biologicals is a crucial step before starting a clinical trial investigation in adult healthy human subjects. Extrapolation of dose between various rodent and non-rodent animal species is critical for biomedical researchers during initial drug development. The objective of this review is to provide practical guidance on how allometric scaling based on the body surface area normalization can be effectively utilized for dose conversion between various animal species. The standard conversion factors are included to allow dose translation between animals to humans and humans to animals expressed either in mg/kg or mg/m2. The estimation of a safe starting dose is important to ensure the safety and tolerability of humans during phase-I clinical trials.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Jacob, S., Nair, A. B., & Morsy, M. A. (2022). Dose Conversion Between Animals and Humans: A Practical Solution. Indian Journal of Pharmaceutical Education and Research, 56(3), 600–607. https://doi.org/10.5530/ijper.56.3.108