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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Cefuroxime Axetil Loaded Dispersed Formulation for Enhanced Drug Release and Antibacterial Activity

Moushumi Tabassoom Salam1, Ashim Kumar1, Md. Abdus Salam2, Mir Imam Ibne Wahed1, Ranjan Kumar Barman1★★ Corresponding author

  1. 1Laboratory of Pharmaceutics, Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, BANGLADESH.
  2. 2Department of Basic Medical Sciences, Faculty of Medicine, International Islamic University, Kuantan, MALAYSIA.

CORRESPONDENCE

Ranjan Kumar Barman

Laboratory of Pharmaceutics, Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, BANGLADESH.

drbarman76@gmail.com

Received: 13-03-2021; Revised: 23-03-2022; Accepted: 21-04-2022.

Volume 56, Issue 3S · pp. S454–S461 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.3s.153

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ABSTRACT

Aim: Aqueous solubility of drugs is a determining factor for bioavailability in systemic circulation and confronts in the unbeaten formulation of therapeutic agents. Cefuroxime axetil (CA) is a broad-spectrum β-lactamase cephalosporin that pertains to class II drugs under Biopharmaceutical Classification System (BCS) with poor aqueous solubility and high absorption permeability after oral administration. The objective of this current work was to achieve the enhanced solubility in water and subsequent antibacterial activity of CA loaded coarse dispersion (CCD) formulations. Materials and Methods: CCDs were prepared by anti-solvent precipitation method by blending CA with a carrier, Microcrystalline cellulose (MCC) at different ratios.In-vitro dissolution test using paddle method and antibacterial study against Staphylococcus aureus (ATCC 25923) andEscherichia coli (ATCC 25922) were carried out for both pure CA and CCDs for performance comparison. Results: Among the formulations, CCD-3 exhibited maximized dissolution rate by 1.67-fold higher than that of pure CA with the drug-carrier (CA: MCC) ratio of 1:3. Antibacterial activity of CCD-3 against S. aureus and E. coli was also found by 1.75-fold and 5.25-fold higher relative zone of inhibition (RZOI), respectively than that of pure drug. Conclusion: As an optimized formulation, CCD-3 is a promising to be a fruitful substitute to conventional dosage forms of CA for the modified dissolution rate and antibacterial potency. However, before its recommendation as a novel formulation validation study to point its pharmacokinetics, competence with in-vivo antibacterial property and safety is needed.

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    Salam, M. T., Kumar, A., Salam, M. A., Wahed, M. I. I., & Barman, R. K. (2022). Cefuroxime Axetil Loaded Dispersed Formulation for Enhanced Drug Release and Antibacterial Activity. Indian Journal of Pharmaceutical Education and Research, 56(3S), S454–S461. https://doi.org/10.5530/ijper.56.3s.153