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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Cobalt and Iron-based Heteroleptic Complexes of Imidazole: Synthesis, Antibacterial and Hemolytic Potential

Kiran Fouzia1, Muhammad Nadeem Akhtar1,2★, Arfan Ali3, Muhammad Babar Taj4, M. Shahid5, Amin Khan6, Muhammad Imran2, Muhammad Shahid7★ Corresponding author

  1. 1Department of Chemistry, University of Agriculture, Faisalabad, PAKISTAN.
  2. 2Division of Inorganic Chemistry, Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, PAKISTAN.
  3. 3Department of Pharmacology, The Islamia University of Bahawalpur, Bahawalpur, PAKISTAN.
  4. 4Department of Chemistry, University of Agriculture, Faisalabad, PAKISTAN.
  5. 5Functional Inorganic Materials Lab (FIML), Department of Chemistry, Aligarh Muslim University, Aligarh, INDIA.
  6. 6Deparment of Chemistry, University of Science and Technology, Bannu, PAKISTAN.
  7. 7Department of Biochemistry, University of Agriculture, Faisalabad, PAKISTAN.

CORRESPONDENCE

Muhammad Nadeem Akhtar

Department of Chemistry, University of Agriculture, Faisalabad, PAKISTAN.

nadeemchem@yahoo.com

Received: 16-03-2021; Revised: 28-11-2021; Accepted: 04-05-2022.

Volume 56, Issue 3S · pp. S515–S521 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.3s.161

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ABSTRACT

Transition metal complexes can deliver exciting properties in the development of metalbased drug system. The aim of current study is to synthesis of metal complexes and to evaluate their biological properties such as antibacterial and hemolytic activity to know their biological importance. Five cobalt and iron-based complexes (1-5), [CoII(imiH)(benz) (N3)] (1) [FeII(imiH)(piv)(N3)] (2), [FeII(imiH)(benz)(N3)] (3), [FeII(imiH)(N3)2] (4), [FeII(imiH) (piv)2] (5), (where imiH = imidazole, piv = pivalic acid, N3- = azide, benz = benzoic acid) were produced by of the reacting of respective metal salts with selective ligands. These complexes were characterized through FTIR and elemental analyses. Compounds (1-5) were tested for their antibacterial biofilm inhibition and hemolytic studies. Complexes of 3 (85.42%) and 2 (69.58%) have promising inhibition forS. aureus whereas 5 (70.48%) and 2 (62.94%) also exhibit significant inhibition against E. coli. The hemolytic study of these metal complexes indicates the cytotoxicity against bovine erythrocytes. The current study will be useful for the development metallodrugs in future.

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    Fouzia, K., Akhtar, M. N., Ali, A., Taj, M. B., Shahid, M., Khan, A., Imran, M., & Shahid, M. (2022). Cobalt and Iron-based Heteroleptic Complexes of Imidazole: Synthesis, Antibacterial and Hemolytic Potential. Indian Journal of Pharmaceutical Education and Research, 56(3S), S515–S521. https://doi.org/10.5530/ijper.56.3s.161