Saccharomyces cerevisiae Catalyzed Synthesis and Evaluation of Pyrazoles
Thangavelu Rajkumar1★, Suresh Kumar Solleti Venkata2, Srinivasan Nagarajan3★ Corresponding author
- 1Department of Pharmaceutical Chemistry, Creative Educational Society’s College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.
- 2Department of Pharmacognosy, Creative Educational Society’s College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.
- 3Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
CORRESPONDENCE
Thangavelu Rajkumar
Department of Pharmaceutical Chemistry, Creative Educational Society’s College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.
Received: 01-02-2022; Revised: 30-05-2022; Accepted: 10-08-2022.
Volume 56, Issue 4S · pp. S695–S702 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.4s.215
ABSTRACT
Background: Biocatalysis in organic solvents has several benefits over aqueous solvents, including solubility of organic substrates, ease of workup, separation of the product, and, in certain cases, reusability of biocatalysts. Materials and Methods: A simple, effective, and environmentally friendly technique for synthesizing pyrazoles has been established, which involves the cyclo condensation of chalcones and isonicotinic acid hydrazide in organic solvents using a relatively inexpensive catalyst baker’s yeast (Saccharomyces cerevisiae). Molecular properties prediction and docking studies were also performed. Results: The predicted molecular properties suggest that the molecules are safe for oral consumption and their docking studies on 2BVC-Mycobacterium tuberculosis glutamine synthetase show their favorable ligand binding nature. The structural assignments were validated based on spectrum data. The compounds were evaluated for their antitubercular, in vitro anti-inflammatory, and anti-oxidant effects. The analysis reveals that synthesized derivatives of pyrazoles possessing methoxy, nitro, hydroxyl, fluoro, and chloro substitution through the phenyl ring help the molecule to increase its pharmacological activities. However, the substituted thiophene ring in the side chain also facilitates the biological action of the molecules. Conclusion: Anti-inflammatory, anti-oxidant, and anti-tubercular properties are due to the presence of the pyrazole ring.
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Rajkumar, T., Venkata, S. K. S., & Nagarajan, S. (2022). Saccharomyces cerevisiae Catalyzed Synthesis and Evaluation of Pyrazoles. Indian Journal of Pharmaceutical Education and Research, 56(4S), S695–S702. https://doi.org/10.5530/ijper.56.4s.215